HEDD

Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

Drug Category

DNA methyltransferase inhibitor(DNMTi)

5-Aza-2'-deoxycytidine (CN:2353-33-5 Molecular Formula:C₈H₁₂N₄O₄)
5-Azacytidine (CN:320-67-2 Molecular Formula:C₈H₁₂N₄O₅)
epigallocatechin-3-gallate (CN:989-51-5 Molecular Formula:C₂₂H₁₈O₁₁)
Zebularine (CN:3690-10-6 Molecular Formula:C₉H₁₂N₂O₅)
hydralazine (CN:86-54-4 Molecular Formula:C₈H₈N₄)
procainamide (CN:51-06-9 Molecular Formula:C₁₃H₂₁N₃O)

Histone acetyltransferases inhibitor(HATi)

C646 (CN:328968-36-1 Molecular Formula:C₂₄H₁₉N₃O₆)
Curcumin (CN:458-37-7 Molecular Formula:C₂₁H₂₀O₆)

Histone deacetylase inhibitor(HDACi)

Suberoylanilide hydroxamic acid (CN:149647-78-9 Molecular Formula:C₁₄H₂₀N₂O₃)
Givinostat (CN:497833-27-9 Molecular Formula:C₂₄H₂₇N₃O₄)
Panobinostat (CN:404950-80-7 Molecular Formula:C₂₁H₂₃N₃O₂)
Trichostatin A (CN:58880-19-6 Molecular Formula:C₁₇H₂₂N₂O₃)
Belinostat (CN:414864-00-9 Molecular Formula:C₁₅H₁₄N₂O₄S)
Entinostat (CN:209783-80-2 Molecular Formula:C₂₁H₂₀N₄O₃)
CG-1521 (CN:674767-29-4 Molecular Formula:C₁₃H₁₃NO₂)
Romidepsin (CN:128517-07-7 Molecular Formula:C₂₄H₃₆N₄O₆S₂)
ITF-A (CN:N.A. Molecular Formula:)
ITF-B (CN:N.A. Molecular Formula:)
Valproic acid (CN:99-66-1 Molecular Formula:C₈H₁₆O₂)
OSU-HDAC-44 (CN:935881-37-1 Molecular Formula:C₁₈H₂₀N₂O₃)
HC-toxin (CN:83209-65-8 Molecular Formula:C₂₁H₃₂N₄O₆)
magnesium valproate (CN:62959-43-7 Molecular Formula:C₁₆H₃₀MgO₄)
plitidepsin (CN:137219-37-5 Molecular Formula:C₅₇H₈₇N₇O₁₅)
Tasquinimod (CN:254964-60-8 Molecular Formula:C₂₀H₁₇F₃N₂O₄)
sodium butyrate (CN:156-54-7 Molecular Formula:C₄H₇NaO₂)
mocetinostat (CN:726169-73-9 Molecular Formula:C₂₃H₂₀N₆O)
carbamazepine (CN:298-46-4 Molecular Formula:C₁₅H₁₂N₂O)
SB939 (CN:929016-96-6 Molecular Formula:C₂₀H₃₀N₄O₂)
CHR-2845 (CN:914382-60-8 Molecular Formula:C₂₈H₃₇N₃O₅)
CHR-3996 (CN:N.A. Molecular Formula:C₂₀H₁₉FN₆O₂)
JNJ-26481585 (CN:875320-29-9 Molecular Formula:C₂₁H₂₆N₆O₂)
Sodium phenylbutyrate (CN:1716-12-7 Molecular Formula:C₁₀H₁₁NaO₂)
Pivanex (CN:122110-53-6 Molecular Formula:C₁₀H₁₈O₄)
Resveratrol (CN:501-36-0 Molecular Formula:C₁₄H₁₂O₃)
abexinostat (CN:783355-60-2 Molecular Formula:C₂₁H₂₃N₃O₅)
resminostat (CN:864814-88-0 Molecular Formula:C₁₆H₁₉N₃O₄S)
dacinostat (CN:404951-53-7 Molecular Formula:C₂₂H₂₅N₃O₃)
Droxinostat (CN:99873-43-5 Molecular Formula:C₁₁H₁₄ClNO₃)

Histone demethylase inhibitor(HDMi)

Pargyline (CN:555-57-7 Molecular Formula:C₁₁H₁₃N)
clorgyline (CN:17780-72-2 Molecular Formula:C₁₃H₁₅C_l2NO)
bizine (CN:N.A. Molecular Formula:C₁₈H₂₄C_lN₃O)
GSK2879552 (CN:1401966-69-5 Molecular Formula:C₂₃H₂₈N₂O₂)
GSK-J4 (CN:1373423-53-0 Molecular Formula:C₂₄H₂₇N₅O₂)
KDM5-C70 (CN:N.A. Molecular Formula:C₁₇H₂₈N₄O₃)
JIB-04 (CN:199596-05-9 Molecular Formula:C₁₇H₁₃ClN₄)
tranylcypromine (CN:155-09-9 Molecular Formula:C₉H₁₁N)

Histone methyltransferase inhibitor(HMTi)

EPZ-6438 (CN:1403254-99-8 Molecular Formula:C₃₄H₄₄N₄O₄)
GSK126 (CN:1346574-57-9 Molecular Formula:C₃₁H₃₈N₆O₂)
CPI360 (CN:N.A. Molecular Formula:C₂₅H₃₁N₃O₄)
3-Deazaneplanocin A (CN:102052-95-9 Molecular Formula:C₁₂H₁₄N₄O₃)
GSK343 (CN:1346704-33-3 Molecular Formula:C₃₁H₃₉N₇O₂)
EI1 (CN:1418308-27-6 Molecular Formula:C₂₃H₂₆N₄O₂)
BIX-01294 (CN:935693-62-2 Molecular Formula:C₂₈H₃₈N₆O₂)
UNC0638 (CN:1255580-76-7 Molecular Formula:C₃₀H₄₇N₅O₂)
EPZ004777 (CN:1338466-77-5 Molecular Formula:C₂₈H₄₁N₇O₄)
UNC0224 (CN:1197196-48-7 Molecular Formula:C₂₆H₄₃N₇O₂)

Inhibitor of protein binding to acetylated histone (PAHi)

JQ1 (CN:1268524-70-4 Molecular Formula:C₂₃H₂₅ClN₄O₂S)
CPI203 (CN:1446144-04-2 Molecular Formula:C₁₈H₁₈ClN₅OS)
RVX-208 (CN:1044870-39-4 Molecular Formula:C₂₀H₂₂N₂O₅)
I-BET151 (CN:1300031-49-5 Molecular Formula:C₂₃H₂₁N₅O₃)
I-BET762 (CN:1260907-17-2 Molecular Formula:C₂₂H₂₂ClN₅O₂)
i-BET-726 (CN:1300031-52-0 Molecular Formula:C₂₅H₂₃ClN₂O₃)

Inhibitor of protein binding to methylated histone(PMHi)

UNC669 (CN:1314241-44-5 Molecular Formula:C₁₅H₂₀BrN₃O)
UNC1215 (CN:1415800-43-9 Molecular Formula:C₃₂H₄₃N₅O₂)

Usefull Links

ZINC
for structure based virtual screening
PubChem Compound
contains validated chemical depiction information
GEO
The granddaddy of epigenomics data repositories
EpiGenie
a list of the best tools and databases for epigenetics researchers
DiseaseMeth
The human disease methylation database
EaSeq
a software environment for ChIP-seq data

HEDD

Welcome to HEDD

Drug Category

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