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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)

PdbId:4BJX
Drug Name:I-BET-726
Target:BROMODOMAIN-CONTAINING PROTEIN 4 (Homo sapiens)
Classification:DNA BINDING PROTEIN
Method:X-RAY DIFFRACTION
Resolution(Å):1.59
Total Weight:18374.56 g/mol
PubmedID:24009722
Citation:Wyce A; Ganji G; Smitheman KN; Chung C; Korenchuk S; Bai Y; Barbash O; Le B; Craggs PD; Mccabe MT; Kennedy-Wilson KM; Sanchez LV; Gosmini RL; Parr N; Mchugh CF; Dhanak D; Prinjha RK; Auger KR; Tummino PJ. Bet Inhibition Silences Expression of Mycn and Bcl2 and Induces Cytotoxicity in Neuroblastoma Tumor Models. (2013) Plos One 8: 72967
Structure:
3D Structure:3D View
Structure Downlaod:4bjx.pdb(140.0KB)
Interaction:

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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