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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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N-Terminal bromodomain of Human BRD2 with I-BET726 (GSK1324726A)

PdbId:4UYF
Drug Name:I-BET-726
Target:BROMODOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)
Classification:TRANSCRIPTION
Method:X-RAY DIFFRACTION
Resolution(Å):1.6
Total Weight:55490.64 g/mol
PubmedID:25249180
Citation:Gosmini R; Nguyen VL; Toum J; Simon C; Brusq M; Krysa G; Mirguet O; Riou-Eymard AM; Boursier EV; Trottet L; Bamborough P; Clark H; Chung CW; Cutler L; Demont EH; Kaur R; Lewis AJ; Schilling MB; Soden PE; Taylor S; Walker AL; Walker MD; Prinjha RK; Nicodeme E. The Discovery of I-Bet726 (Gsk1324726A), a Potent Tetrahydroquinoline Apoa1 Up-Regulator and Selective Bet Bromodomain Inhibitor. (2014) J.Med.Chem. 57: 8111
Structure:
3D Structure:3D View
Structure Downlaod:4uyf.pdb(551.0KB)
Interaction:

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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