Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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High-throughput Dataset

TitleDrug NameCategorySample typePMID
RNAseq to investigate transcriptional changes in human MM cell lines due to panobinostat, 5-Azacytidine, panobinostat+5-Azacytidine or n-methyl-2-pyrroldine (NMP) treatments. 5-Azacytidine
Panobinostat
DNMTi
HDACi
human Multiple myeloma cell lines24030150
24813887
Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes (methylation) 5-Aza-2'-deoxycytidine
clorgyline
DNMTi
HDMi
human bladder cancer cell line (T-24); human leukemia cell line (HL60); human colon cancer cell line (HCT116)24040395
Investigate the anti-tumor mechanisms of But4ManNAc and butyrate in two breast cancer cell lines sodium butyrateHDACihuman metastatic breast cancer cells (MDA-MB-231)
Alternative splicing in HeLa cells after sodium butyrate treatment sodium butyrateHDACiHeLa cells21311748
DNA Methyltransferase inhibition reverses epigenetically embedded phenotypes in lung cancer preferentially affecting Polycomb target genes 5-Azacytidine DNMTihomo non-small cell lung cancer (NSCLC) cell lines (A549 and HTB56)24334763
Identification and functional analysis of epigenetically silenced microRNAs in colorectal cancer cells 5-Aza-2'-deoxycytidine DNMTihuman colorectal cancer cells 21698188
Gene expression profiles of ovarian cancer cell lines in the presence and absence of a DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine DNMTihuman epithelial ovarian cancer cell lines21156726
18836486
DNA Methyltransferase Inhibitor Zebularine Induces Human Cholangiocarcinoma Cell Death through Alteration of DNA Methylation Status Zebularine DNMTiHuman Cholangiocarcinoma Cell lines (TFK1 and HuCCT1)25799509
Gene expression profiles of ovarian cancer cell lines in the presence and absence of a DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine
epigallocatechin-3-gallate
DNMTihuman regulatory T cells 24476360
Treatment of renal cell carcinoma cell line A-498 with zebularine Zebularine DNMTihuman renal cell carcinoma cell line (A-498)
Treatment of prostate cancer cell lines DU-145 and LNCaP with zebularine Zebularine DNMTihuman prostate cancer cell lines (DU-145 and LNCaP)
Real-time quantitative PCR analysis of Wnt signalling in human prostate cancer 5-Aza-2'-deoxycytidine DNMTihuman prostate cancer cell
Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting 5-azacytidine DNMTiT cells from volunteer donor19887673
Gene expression profiling of oral cancer cell lines with or without AzC treatment 5-Aza-2'-deoxycytidine DNMTihumen oral cancer cell lines 23362108
Ras-induced epigenetic inactivation of RRAD promotes glucose uptake in a human ovarian cancer model [DGE-Seq] 5-Aza-2'-deoxycytidine DNMTihuman ovarian cancer cells (T29 and T29H)24648519
Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting 5-azacytidine DNMTihuman T lymphocytes 24583822
DNA methyltransferase inhibitor zebularine inhibits human hepatic carcinoma cells proliferation and induces apoptosis. Zebularine DNMTiHuman hepatocellular carcinoma cell line (HepG2)23320119
Genome-wide microRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers 5-Aza-2'-deoxycytidine
trichostatin A
DNMTi
HDACi
human non-small cell lung cancers cells (A549) 22282464
Expression profiling of DNMT1 inhibitors in HCT116 cells 5-Aza-2'-deoxycytidine DNMTihuman HCT116 cells
Aplidin synergizes with cytosine arabinoside: functional relevance of mitochondria in Aplidin-induced cytotoxicity plitidepsin
5-Azacytidine
HDACi
DNMTi
human diffuse large B cell lymphoma cell line (SKI-DLCL cells)17713546
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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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