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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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5-Aza-2'-deoxycytidine

Category:DNMTi
Cas Number:2353-33-5
Molecular Formula:C8H12N4O4
Molecular Weight:228.20528 g/mol
Smiles:C1C(C(OC1N2C=NC(=NC2=O)N)CO)O
Description:5-Aza-2'-deoxycytidine is a cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (5.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
1 5-Aza-2'-deoxycytidineexonuclease V (RecBCD complex), alpha chain (Escherichia coli str. K-12 substr. MG1655)

Disease list

ConditionsDrug NameStatusNct NumberPhases
myelodysplastic syndromes
MDS
5-Aza-2'-deoxycytidineCompletedapproved(N21790)
MDS5-Aza-2'-deoxycytidine CompletedNCT00796003Phase 1
Leukemia
MDS
5-Aza-2'-deoxycytidine CompletedNCT00049582Phase 1
Bladder cancer
breast cancer
melanoma
5-Aza-2'-deoxycytidine CompletedNCT00030615Phase 1
Esophageal
lung cancer
malignant mesothelioma
5-Aza-2'-deoxycytidine CompletedNCT00019825Phase 1
Leukemia5-Aza-2'-deoxycytidine CompletedNCT00042796Phase 1
MDS
leukemia
lymphoma
MM
5-Aza-2'-deoxycytidine CompletedNCT00002980Phase 1
Myeloproliferative disorders
leukemia
5-Aza-2'-deoxycytidine
Suberoylanilide hydroxamic acid
CompletedNCT00357708Phase 1
Unspecified adult solid tumor5-Aza-2'-deoxycytidine
PEG-interferon alfa-2b
CompletedNCT00701298Phase 1
Cancer5-Aza-2'-deoxycytidine
pegylated interferon-alfa 2b
TerminatedNCT00886457Phase 1
Lymphoma5-Aza-2'-deoxycytidine
Valproic acid
CompletedNCT00109824Phase 1
SCCjmesothelioma|NSCLC5-Aza-2'-deoxycytidine
romidepsin
CompletedNCT00037817Phase 1
LeukemiajMDS5-Aza-2'-deoxycytidine
Suberoylanilide hydroxamic acid
CompletedNCT00479232Phase 1
Neuroblastoma
childhood solid tumor
5-Aza-2'-deoxycytidine
filgrastim
pegfilgrastim
cyclophosphamide
doxorubicin hydrochloride
CompletedNCT00075634Phase 1
Leukemia
MDS
5-Aza-2'-deoxycytidine
romidepsin
CompletedNCT00114257Phase 1
Leukemia
acute myelodysplastic syndromes
Suberoylanilide hydroxamic acid
5-Aza-2'-deoxycytidine
CompletedNCT00479232Phase 1
Leukemia
lymphoma
MDS syndrome
Romidepsin
5-Aza-2'-deoxycytidine
CompletedNCT00114257Phase 1
Small cell lung carcinoma5-Aza-2'-deoxycytidine
depsipeptide
CompletedNCT00037817Phase 1
Lymphoma
intestinal neoplasms
5-Aza-2'-deoxycytidine CompletedNCT00089089Phase 1
Leukemia5-Aza-2'-deoxycytidine CompletedNCT01378416Phase 1
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High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes (methylation) 5-Aza-2'-deoxycytidine
clorgyline
DNMTi
HDMi
human bladder cancer cell line (T-24); human leukemia cell line (HL60); human colon cancer cell line (HCT116)24040395
Identification and functional analysis of epigenetically silenced microRNAs in colorectal cancer cells 5-Aza-2'-deoxycytidine DNMTihuman colorectal cancer cells 21698188
Gene expression profiles of ovarian cancer cell lines in the presence and absence of a DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine DNMTihuman epithelial ovarian cancer cell lines21156726
18836486
Gene expression profiles of ovarian cancer cell lines in the presence and absence of a DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine
epigallocatechin-3-gallate
DNMTihuman regulatory T cells 24476360
Real-time quantitative PCR analysis of Wnt signalling in human prostate cancer 5-Aza-2'-deoxycytidine DNMTihuman prostate cancer cell
Gene expression profiling of oral cancer cell lines with or without AzC treatment 5-Aza-2'-deoxycytidine DNMTihumen oral cancer cell lines 23362108
Ras-induced epigenetic inactivation of RRAD promotes glucose uptake in a human ovarian cancer model [DGE-Seq] 5-Aza-2'-deoxycytidine DNMTihuman ovarian cancer cells (T29 and T29H)24648519
Genome-wide microRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers 5-Aza-2'-deoxycytidine
trichostatin A
DNMTi
HDACi
human non-small cell lung cancers cells (A549) 22282464
Expression profiling of DNMT1 inhibitors in HCT116 cells 5-Aza-2'-deoxycytidine DNMTihuman HCT116 cells
Genome-wide DNA Methylation Analysis Reveals Novel Targets for Drug Development in Mantle Cell Lymphoma 5-aza-2'-deoxycytidine
Suberoylanilide hydroxamic acid
DNMTi
HDACi
human Mantle Cell Lymphoma (MCL) lines Mantle Cell Lymphoma (MCL) patients20427703
Expression data identifying hypermethylated genes associated with acquired cisplatin resistance 5-Aza-2'-deoxycytidine DNMTihuman Cisplatin-sensitive and -resistant SCC cells20215521
DNA methylation of developmental genes in pediatric medulloblastomas identified by DAMD 5-Aza-2'-deoxycytidine DNMTihuman medulloblastoma cell lines human colon Cancer Cell Line (HCT116)19966297
Prostate_5azadC 5-Aza-2'-deoxycytidine DNMTihuman prostate cancer cell lines (LNCaP,DU145,PC3,MDA-2A)16166285
Identification of epigenetically silenced genes in tumor endothelial cells Trichostatin A
5-Aza-2'-deoxycytidine
DNMTi
HDACi
human tumor endothelial cells17483324
Specific molecular signatures underlie response to decitabine in CMML [RNA-seq] 5-Aza-2'-deoxycytidine DNMTimRNA profiling in bone marrow mononuclear cells (BM MNC) from 14 CMML patients;bone marrow mononuclear cells (BM MNC) from 39 CMML patients 25822018
Effects of DNA methyltransferase inhibitors (DNMTIs) on MDS-derived cell lines 5-Aza-2'-deoxycytidineDNMTihuman MDS-derived cell lines
Effects of DZNep and 5-Aza-CdR on gene expression in MCF7 cells after 72 h treatment 5-Aza-2'-deoxycytidineDNMTihuman breast adenocarcinoma cell lines19509260
CCAAT/enhancer-binding protein alpha is epigenetically silenced by histone acetylation in endometriosis and promotes the pathogenesis of endometriosis: a novel therapeutic target 5-Aza-2'-deoxycytidine
Valproic acid
DNMTi
HDACi
human endometriotic cyst stromal cells (ECSCs)23833041
A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2'-dC upon inhibition of ribonucleotide reductase-wide 5-Aza-2'-deoxycytidine
Resveratrol
DNMTi
HDACi
human myeloid leukemia cell lines26468331
Identification of novel metastases-suppressor genes involved in breast cancer brain metastases (BCBM) formation 5-Aza-2'-deoxycytidine DNMTi human primary breast cancer cells (MDA-MB-231)24833255
Total Page:3

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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