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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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Belinostat

Category:HDACi
Cas Number:414864-00-9
Molecular Formula:C15H14N2O4S
Molecular Weight:318.34766 g/mol
Smiles:C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C=CC(=O)NO
Description:Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (6.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
817 BelinostatHistone deacetylase (Homo sapiens (human))21634430
818 BelinostatHistone deacetylase 4 (HDAC4) (Homo sapiens (Human))21634430
819 BelinostatHistone deacetylase 3 (Homo sapiens (human))21634430
820 BelinostatHistone deacetylase (HDAC1 and HDAC2) (Homo sapiens (human))21634430
821 BelinostatHistone deacetylase 8 (Homo sapiens (human))21634430
822 BelinostatHistone deacetylase 9 (HDAC9) (Homo sapiens (Human))21634430
823 BelinostatHistone deacetylase 5 (HDAC5) (Homo sapiens (Human))21634430
824 BelinostatHistone deacetylase 1 (HDAC1) (Homo sapiens (human))21634430
825 BelinostatHistone deacetylase (Homo sapiens (human))21634430
826 BelinostatHistone deacetylase (Homo sapiens (human))21634430
827 BelinostatHistone Deacetylase 10 (HDAC10) (Homo sapiens (human))21634430
828 BelinostatVoltage-gated potassium channel (Homo sapiens (human))21742496
829 BelinostatHistone deacetylase 1 (HDAC1) (Homo sapiens (human))21742496
830 BelinostatHistone deacetylase (Homo sapiens (human))18308563
831 BelinostatCytochrome P450 3A (Homo sapiens (human))21742496
832 BelinostatHistone deacetylase 4 (HDAC4) (Homo sapiens (Human))18308563
833 BelinostatHistone Deacetylase 4 (HDAC4) Mutant (H976Y) (Homo sapiens (human))18308563
834 BelinostatVoltage-gated potassium channel (Homo sapiens (human))21650221
835 BelinostatHistone deacetylase 3 (Homo sapiens (human))18308563
836 BelinostatHistone deacetylase 1 (HDAC1) (Homo sapiens (human))18308563
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Disease list

ConditionsDrug NameStatusNct NumberPhases
peripheral T-cell lymphoma
PTCL
BelinostatCompletedapproved(NDA206256)
Non-small-cell lung carcinomaBelinostat
carboplatin
paclitaxel and bevacizumab
TerminatedNCT01090830Phase 1 2
Non small cell lung cancerBelinostat
erlotinib
TerminatedNCT01188707Phase 1 2
De novo myelodysplastic syndromesBelinostatCompletedNCT01647009Phase 2
Multiple myelomaBelinostat
dexamethasone
CompletedNCT00131261Phase 2
healthyValproic acid
trichostatin A
Suberoylanilide hydroxamic acid
Belinostat
Panobinostat
Entinostat
Preclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation, and optimization for histone deacetylase inhibitors Valproic acid
trichostatin A
Suberoylanilide hydroxamic acid
Belinostat
Panobinostat
Entinostat
HDACihuman embryonic stem cells (hESCs)26272509

Complex list

PDBIdDrug NameTargetmethodPubmedId
5EEN BelinostatHdac6 protein (Danio rerio) X-RAY DIFFRACTION 27454933

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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