CG-1521
Category: | HDACi |
Cas Number: | 674767-29-4 |
Molecular Formula: | C13H13NO2 |
Molecular Weight: | 215.24782 g/mol |
Smiles: | C1=CC=C(C=C1)C=CC=CC=CC(=O)NO |
Description: | Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains. |
synonyms: | |
Structure: | ![]() |
3D Conformer: | 3D View |
Downlaod: | Structure File Download (5.0KB) |
Target list
Id | Drug Name | Target | PubmedId | Co-crystal Complex |
Disease list
Conditions | Drug Name | Status | Nct Number | Phases |
Prostate Cancer | Trichostatin A CG-1521 | Preclinical study | ||
Inflammatory Breast Cancer | CG-1521 | Preclinical study |
High-throughoutput Dataset
Title | Drug Name | Category | Sample type | PMID |
7.5uM CG-1521 and 5uM TSA treatment of LNCaP Prostate Cancer cells | Trichostatin A CG-1521 | HDACi | human LNCaP Prostate Cancer cells | 18645003 |
Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas | CG-1521 | HDACi | Inflammatory Breast Cancer Cells SUM149PT and SUM190PT cells |
Complex list
PDBId | Drug Name | Target | method | PubmedId |