HEDD

Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

CG-1521

Category:	HDACi
Cas Number:	674767-29-4
Molecular Formula:	C₁₃H₁₃NO₂
Molecular Weight:	215.24782 g/mol
Smiles:	C1=CC=C(C=C1)C=CC=CC=CC(=O)NO
Description:	Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains.
synonyms:	CG-1521 UNII-028K52V859 N-hydroxy-7-phenylhepta-2,4,6-trienamide 2,4,6-Heptatrienamide, N-hydroxy-7-phenyl-, (2E,4E,6E)- CHEMBL159249 SCHEMBL10323570 674767-29-4 LP063755 N-Hydroxy-7-phenyl-2,4,6-heptatrienamide 028K52V859 (2E,4E,6E)-N-HYDROXY-7-PHENYLHEPTA-2,4,6-TRIENAMIDE
Structure:
3D Conformer:	3D View
Downlaod:	Structure File Download (5.0KB)

Target list

Drug Name

Target

PubmedId

Co-crystal Complex

Disease list

Conditions	Drug Name	Status	Nct Number	Phases
Prostate Cancer	Trichostatin A CG-1521			Preclinical study
Inflammatory Breast Cancer	CG-1521			Preclinical study

High-throughoutput Dataset

Title	Drug Name	Category	Sample type	PMID
7.5uM CG-1521 and 5uM TSA treatment of LNCaP Prostate Cancer cells	Trichostatin A CG-1521	HDACi	human LNCaP Prostate Cancer cells	18645003
Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas	CG-1521	HDACi	Inflammatory Breast Cancer Cells SUM149PT and SUM190PT cells

Complex list

PDBId

Drug Name

Target

method

PubmedId

About

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.