Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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CG-1521

Category:HDACi
Cas Number:674767-29-4
Molecular Formula:C13H13NO2
Molecular Weight:215.24782 g/mol
Smiles:C1=CC=C(C=C1)C=CC=CC=CC(=O)NO
Description:Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (5.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex

Disease list

ConditionsDrug NameStatusNct NumberPhases
Prostate CancerTrichostatin A
CG-1521
Preclinical study
Inflammatory Breast CancerCG-1521Preclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
7.5uM CG-1521 and 5uM TSA treatment of LNCaP Prostate Cancer cells Trichostatin A
CG-1521
HDACi human LNCaP Prostate Cancer cells18645003
Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas CG-1521HDACiInflammatory Breast Cancer Cells SUM149PT and SUM190PT cells

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

Copyright

©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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