Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

read more

Romidepsin

Category:HDACi
Cas Number:128517-07-7
Molecular Formula:C24H36N4O6S2
Molecular Weight:540.69584 g/mol
Smiles:CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C
Description:Romidepsin is a bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum with antineoplastic activity. After intracellular activation, romidepsinbinds to and inhibits histone deacetylase (HDAC), resulting in alterations in gene expression and the induction of cell differentiation, cell cycle arrest, and apoptosis. This agent also inhibits hypoxia-induced angiogenesis and depletes several heat shock protein 90 (Hsp90)-dependent oncoproteins.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (8.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
927 RomidepsinHistone deacetylase 1 (HDAC1) (Homo sapiens (human))17958342
928 RomidepsinHistone Deacetylase 6 (HDAC6) (Mus musculus)17958342
929 RomidepsinHistone deacetylase (Homo sapiens (human))
930 RomidepsinHistone deacetylase (HDAC1 and HDAC2) (Homo sapiens (human))
931 RomidepsinHistone deacetylase 1 (HDAC1) (Homo sapiens (human))
932 RomidepsinHistone deacetylase 3/Nuclear receptor corepressor 2 (Homo sapiens (human))
933 RomidepsinHistone deacetylase 1 (HDAC1) (Homo sapiens (human))23021104
934 RomidepsinHistone deacetylase (Homo sapiens (human))23021104
935 RomidepsinHistone deacetylase (Homo sapiens (human))23021104
936 RomidepsinHistone deacetylase 4 (HDAC4) (Homo sapiens (Human))23021104
937 RomidepsinHistone deacetylase 1 (HDAC1) (Homo sapiens (human))23021104

Disease list

ConditionsDrug NameStatusNct NumberPhases
cutaneous T cell lymphoma
CTCL
RomidepsinCompletedapproved(NDA022393)
SCCjmesothelioma|NSCLC5-Aza-2'-deoxycytidine
romidepsin
CompletedNCT00037817Phase 1
Leukemia
MDS
5-Aza-2'-deoxycytidine
romidepsin
CompletedNCT00114257Phase 1
Hematologic cancerRomidepsin
ketoconazole
CompletedNCT01324310Phase 1
Mycosis fungoides
CTCL
neoplasms
RomidepsinTerminatedNCT01445340Phase 1
Hematologic cancerRomidepsin
rifampin
CompletedNCT01324323Phase 1
NeoplasmsRomidepsin CompletedNCT00048334Phase 1
Leukemia
lymphoma
RomidepsinCompletedNCT00024180Phase 1
LymphomaRomidepsinCompletedNCT00019318Phase 1
Leukemia
lymphoma
MDS syndrome
Romidepsin
5-Aza-2'-deoxycytidine
CompletedNCT00114257Phase 1
Nervous system tumors
leukemia
RomidepsinCompletedNCT00053963Phase 1
Pancreatic cancerRomidepsin
gemcitabine
CompletedNCT00379639Phase 1 2
Multiple myelomaRomidepsin
bortezomib
TerminatedNCT00765102Phase 2
Peritoneal
epithelial
ovarian cancer
RomidepsinCompletedNCT01645670Phase 2
LymphomaRomidepsinCompletedNCT00383565Phase 2
Cutaneous T-cell lymphomaRomidepsin CompletedNCT00106431Phase 2
LymphomaRomidepsin
rituximab
fludarabine
CompletedNCT00079443Phase 2
Brain and nervous system tumorsRomidepsinCompletedNCT00085540Phase 2
Lung cancerRomidepsinCompletedNCT00086827Phase 2
Colorectal cancerRomidepsinCompletedNCT00077337Phase 2
Total Page:2 Page   of 2

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
HDAC Inhibitors induce tumor cell-selective pro-apoptotic transcriptional responses Suberoylanilide hydroxamic acid
Romidepsin
HDACihuman tumor cell lines(BJ and BJ LTSTERas cells) 23449455
Gene expression profiles of HCT116 colorectal carcinoma cells treated with HDAC inhibitors Suberoylanilide hydroxamic acid
Romidepsin
HDACihuman HCT116 colorectal carcinoma cells20739454
Inhibition of class I histone deacetylases 1 and 2 promotes urothelial carcinoma cell death by various mechanisms (HDAC inhibitor treatments) Suberoylanilide hydroxamic acid
Romidepsin
Givinostat
abexinostat
HDACihuman VM-CUB1 cells human UM-UC-3 cells26772204
Inhibition of class I histone deacetylases 1 and 2 promotes urothelial carcinoma cell death by various mechanisms (HDAC inhibitor treatments) Romidepsin
Givinostat
Suberoylanilide hydroxamic acid
HDACiVM-CUB1 and UM-UC-3 cells26772204
Romidepsin and azacitidine synergize in their epigenetic modulatory effects to induce apoptosis in CTCL romidepsinHDACiCTCL cell lines as well as CD4+ T cells derived from patients with Sézary Syndrome (SS) with high tumor burden26660520
Comparison between HuT78 parental and romidpepsin-selected cell lines romidepsinHDACiHuT78 cutaneous T-cell lymphoma (CTCL) cells23532732
Examination of the MAPK pathway gene expression in patient samples romidepsinHDACipatient blood samples23532732

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

pix

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

Copyright

©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

吉ICP备16005872号