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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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Valproic acid

Category:HDACi
Cas Number:99-66-1
Molecular Formula:C8H16O2
Molecular Weight:166.193269 g/mol
Smiles:CCCC(CCC)C(=O)O
Description:Valproic Acid is a synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. (NCI04)
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (4.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
938 valproic acidAcyl-CoA: cholesterol acyltransferase (ACAT) (Homo sapiens (Human))23386702
939 valproic acidUDP-glucuronosyltransferase 2B7 (Homo sapiens)15781124
940 valproic acidCarboxylesterase 2 (Homo sapiens)23386702
941 valproic acidCytochrome P450 2A6 (Homo sapiens (Human))16248836
942 valproic acidCoagulation factor VII/tissue factor (Homo sapiens)17675290
943 valproic acidHistone deacetylase 1 (HDAC1) (Homo sapiens (human))21874153
944 valproic acidistone deacetylase (HDAC1 and HDAC2) (Homo sapiens (human))21874153
945 valproic acidHistone deacetylase 3 (Homo sapiens (human))21874153
946 valproic acidHistone deacetylase 8 (Homo sapiens (human))21874153
947 valproic acidHistone deacetylase 4 (HDAC4) (Homo sapiens (Human))21874153
948 valproic acidHistone deacetylase 5 (HDAC5) (Homo sapiens (Human))21874153
949 valproic acidHistone deacetylase (Homo sapiens (human))21874153
950 valproic acidHistone deacetylase 9 (HDAC9) (Homo sapiens (Human))21874153
951 valproic acidHistone deacetylase (Homo sapiens (human))21874153
952 valproic acidAldose reductase (Rattus norvegicus)23312612
953 valproic acidAldose reductase (Rattus norvegicus)24630695
954 valproic acidAldose reductase-related protein 1 (Rattus norvegicus)25695864
955 valproic acidAldose reductase (Bos taurus)26005026
956 valproic acidCoagulation factor VII/tissue factor (Homo sapiens)17675290
957 valproic acidAldehyde reductase (Homo sapiens (human))20936791
Total Page:2 Page   of 2

Disease list

ConditionsDrug NameStatusNct NumberPhases
Advanced cancers5-Azacytidine
valproic acid
CompletedNCT00496444Phase 1
Brain metastasesTemozolomide
valproic acid
TerminatedNCT00437957Phase 1
HIV infectionsEnfuvirtide
valproic acid
TerminatedNCT00312546Phase 1
Lymphoma5-Aza-2'-deoxycytidine
Valproic acid
CompletedNCT00109824Phase 1
MDS
AML
5-Azacytidine
Valproic acid
ATRA
CompletedNCT01575691Phase 1
Advanced cancers5-Azacytidine
Valproic acid
CompletedNCT00496444Phase 1
Malignant melanomaKarenitecin
valproic acid
TerminatedNCT00358319Phase 1 2
ALPS|hypersplenism|lymphadenopathyValproic acidCompletedNCT00605657Phase 1 2
Leukemia
MDS
5-Aza-2'-deoxycytidine
Valproic acid
CompletedNCT00075010Phase 1 2
Chronic lymphocytic leukemiaValproic acid
fludarabine
TerminatedNCT00524667Phase 2
Myelodysplastic syndromes5-Azacytidine
valproic acid
ATRA
CompletedNCT00439673Phase 2
AML
MDS
5-Azacytidine
valproic acid
retinoic acid
CompletedNCT00339196Phase 2
HIV infectionsRaltegravir
valproic acid
TerminatedNCT00614458Phase 2
AML|MDS5-Azacytidine
Valproic acid
ATRA
CompletedNCT00339196Phase 2
MDSs5-Azacytidine
Valproic acid
ATRA
CompletedNCT00439673Phase 2
MDS

AML
5-Azacytidine
Valproic acid
ATRA
CompletedNCT00326170Phase 2
AML
MDS
leukemia
5-Azacytidine
Ara-C
Valproic acid
CompletedNCT00382590Phase 2
HTLV-I-associated myelopathyValproic acidTerminatedNCT00519181PHN.A
lymphoma cell leu-kemiaSuberoylanilide hydroxamic acid
Valproic acid
Preclinical study
epilepsyValproic acidPreclinical study
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High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Transcriptional response to histone deacetylase inhibitors Suberoylanilide hydroxamic acid
Valproic acid
HDACihuman lymphoma cell leu-kemia cells (LCL cells)
Expression data from untreated and valproic acid (VPA) treated CD34+ Hematopoietic Stem Cells (HSCs) Valproic acidHDACihuman CD34+ cells22885124
A Multi-loop, Double-cube Microarray Design Applied to Prostate Cancer Cell Lines with Variable Sensitivity to Histone Deacetylase Inhibitor Suberoylanilide hydroxamic acid
Valproic acid
HDACi human Prostate Cancer Cell Lines (DU-145 and PC3)18980983
Gene expression of VPA and GEM Valproic acidHDACihuman cholangiocarcinoma cell line (HuCCT1)
BCL6 repression of EP300 provides a basis for rational combinatorial therapy in diffuse large B cell lymphomas Suberoylanilide hydroxamic acid
Valproic acid
Trichostatin A
HDACihuman diffuse large B-cell lymphomas cell lines (DLBCL cell lines)21041953
Antileukemic activity of valproic acid in chronic lymphocytic leukemia cells defined by microarray analysis Valproic acidHDACichronic lymphocytic leukemia cells obtained from 14 patients 19710697
Valproic Acid Confers Functional Pluripotency to Human Amniotic Fluid Stem Cells in a Transgene-free Approach Valproic acidHDACi human Amniotic Fluid Stem Cells human embryonic stem cells22760542
Profile of gene expression in K562 cells exposed to 2 mM sodium valproate for 12 hours using Agilent SurePrint G3 Human GE 8x60K Microarray Valproic acidHDACihuman K562 cells22701306
A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation, and optimization for histone deacetylase inhibitors Valproic acid
trichostatin A
Suberoylanilide hydroxamic acid
Belinostat
Panobinostat
Entinostat
HDACihuman embryonic stem cells (hESCs)26272509
Gene expression profiles of Histone deacetylase inhibitors treated cord blood hematopoietic stem cells. Valproic acidHDACihuman cord blood CD34+ cells
CCAAT/enhancer-binding protein alpha is epigenetically silenced by histone acetylation in endometriosis and promotes the pathogenesis of endometriosis: a novel therapeutic target 5-Aza-2'-deoxycytidine
Valproic acid
DNMTi
HDACi
human endometriotic cyst stromal cells (ECSCs)23833041
In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells. valproic acidHDACiHuman skin-derived precursor cells (hSKP)25716160
U937 treated with decitabine, panobinostat and valproic acid 5-Aza-2'-deoxycytidine
panobinostat
valproic acid
DNMTi
HDACi
AML cell line model U937
OCI/AML2 ATRA AND VPA GENE EXPRESSION valproic acid HDACiOCI/AML-2 cells15902297
Theca cell gene expression valproic acidHDACiPolycystic ovary syndrome (PCOS) theca cells15598877
Human embryonic stem cell based neuro-developmental toxicity assay: response to valproic acid and carbamazepine exposure valproic acid
carbamazepine
HDACihuman embryonic stem cell (hESC)25979313
Toxicology study on KhES-3 cells. valproic acidHDACihuman embryonic stem cell (hESC)
Gene expression in INA6 multiple myeloma cells in an acidic condition valproic acidHDACiINA6 multiple myeloma cells
Expression data for developing a GE-HTS signature for neuroblastoma differentiation valproic acidHDACiBE(2)-C cells
Gene expression profile of the human leukemia cell line Reh after treatment with bortezomib, valproic acid or a combination of both. valproic acidHDACihuman leukemia cell line Reh23357978
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Complex list

PDBIdDrug NameTargetmethodPubmedId

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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