Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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HC-toxin

Category:HDACi
Cas Number:83209-65-8
Molecular Formula:C21H32N4O6
Molecular Weight:436.50198 g/mol
Smiles:CC1C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C)CCCCCC(=O)C3CO3
Description:
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (8.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex

Disease list

ConditionsDrug NameStatusNct NumberPhases
neuroblastomaHC-toxinPreclinical study
neuroblastomaHC-toxinPreclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma HC-toxinHDACihuman BE(2)-C neuroblastoma cells 23625969
Stimulating BMP4 signaling via HDAC11 inhibition suppresses malignancy in preclinical models of human neuroblastoma HC-toxinHDACiBE(2)C neuroblastoma cells

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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