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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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magnesium valproate

Category:HDACi
Cas Number:62959-43-7
Molecular Formula:C16H30MgO4
Molecular Weight:310.712 g/mol
Smiles:CCCC(CCC)C(=O)[O-].CCCC(CCC)C(=O)[O-].[Mg+2]
Description:Magnesium Valproate is the magnesium salt of valproic acid (2-propylpentanoic acid) with antiepileptic and potential antineoplastic activities. Magnesium valproate dissociates in the gastrointestinal tract and is absorbed into the circulation as magnesium ions and valproic acid ions; valproic acid may inhibit histone deacetylases, inducing tumor cell differentiation, apoptosis, and growth arrest. In addition, valproic acid exerts an antiepileptic effect, likely by inhibiting enzymes that catabolize the inhibitory neurotransmittergamma-aminobutyric acid (GABA) catabolism and so increasing concentrations of GABA in the central nervous system (CNS). The presence of the magnesium in this agent may contribute to its anticonvulsant activity and sedative properties.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (4.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex

Disease list

ConditionsDrug NameStatusNct NumberPhases
Cervical cancerHydralazine
magnesium valproate
CompletedNCT00404326Phase 2
Locally advanced breast cancerHydralazine
magnesium valproate
TerminatedNCT00395655Phase 2
Refractory solid tumorsHydralazine
magnesium valproate
CompletedNCT00404508Phase 2
carcinoma of the cervixhydralazine
magnesium valproate
Preclinical study
primary breast cancerhydralazine
magnesium valproate
Preclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Epigenetic therapy with hydralazine and magnesium valproate added to chemoradiation in cervical carcinoma. hydralazine
magnesium valproate
DNMTi
HDACi
Previously untreated patients with histological diagnosis of carcinoma of the cervix and FIGO
Gene Expression Profiles of Epigenetic treatment in primary breast cancer. hydralazine
magnesium valproate
DNMTi
HDACi
The patients with primary breast cancer17183730

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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