Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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plitidepsin

Category:HDACi
Cas Number:137219-37-5
Molecular Formula:C57H87N7O15
Molecular Weight:1110.33858 g/mol
Smiles:CCC(C)C1C(CC(=O)OC(C(=O)C(C(=O)NC(C(=O)N2CCCC
2C(=O)N(C(C(=O)OC(C(C(=O)N1)NC(=O)
Description:Plitidepsin is a compound found in tunicates which shows promise in shrinking tumors in pancreatic, stomach, bladder, and prostate cancers. The specific marine organism isAplidium albicans. Aplidine consists of peptide molecules. In addition to the cancers mentioned above it is also under consideration as a treatment for some types of leukemia.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (0.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex

Disease list

ConditionsDrug NameStatusNct NumberPhases
diffuse large B cell lymphomaplitidepsin
5-Azacytidine
Preclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Aplidin synergizes with cytosine arabinoside: functional relevance of mitochondria in Aplidin-induced cytotoxicity plitidepsin
5-Azacytidine
HDACi
DNMTi
human diffuse large B cell lymphoma cell line (SKI-DLCL cells)17713546

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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