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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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sodium butyrate

Category:HDACi
Cas Number:156-54-7
Molecular Formula:C4H7NaO2
Molecular Weight:110.086949 g/mol
Smiles:CCCC(=O)[O-].[Na+]
Description:Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes.Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (2.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
961 sodium butyratebeta-Carbonic Anhydrase (Candida albicans (Yeast))19297172
962 sodium butyrateCarbonic Anhydrase I (Homo sapiens (human))21402476
963 sodium butyrateCarbonic Anhydrase II (Homo sapiens (human))19297172
964 sodium butyrateCoagulation factor VII/tissue factor (Homo sapiens)17675290
965 sodium butyrateCoagulation factor VII/tissue factor (Homo sapiens)17675290

Disease list

ConditionsDrug NameStatusNct NumberPhases
myelogenous leukemiasodium butyrate
Suberoylanilide hydroxamic acid
Preclinical study
monocyte-derived dendriticSodium butyratePreclinical study
colorectal cancersodium butyratePreclinical study
Colorectal CancerSodium butyratePreclinical study
colon adenocarcinomasodium butyratePreclinical study
healthysodium butyratePreclinical study
healthysodium butyratePreclinical study
healthysodium butyratePreclinical study
healthysodium butyrate
3-Deazaneplanocin A
Preclinical study
healthysodium butyratePreclinical study
metastatic breast cancersodium butyratePreclinical study
cervical cancersodium butyrate Preclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Investigate the anti-tumor mechanisms of But4ManNAc and butyrate in two breast cancer cell lines sodium butyrateHDACihuman metastatic breast cancer cells (MDA-MB-231)
Alternative splicing in HeLa cells after sodium butyrate treatment sodium butyrateHDACiHeLa cells21311748
HDAC inhibitors cause site-specific chromatin remodeling at PU.1-bound enhancers in K562 cells sodium butyrate
Suberoylanilide hydroxamic acid
HDACihuman the myelogenous leukemia cell lines (K562)
The effect of short-chain fatty acids (SCFAs) on human monocyte-derived dendritic cells (DCs) Sodium butyrateHDACihuman monocyte-derived dendritic cells
The Warburg effect alters histone acetylation in cancer cells by influencing the utilization of HDAC and HAT mechanisms sodium butyrateHDACihuman control cells (siMock); human ACL-depleted (siACL) cells
The Warburg effect alters histone acetylation in cancer cells by influencing the utilization of HDAC and HAT mechanisms Sodium butyrateHDACihuman Colorectal Cancer cells24716727
Gene expression profile of ATF6a and ATF6b overexpression in LS174T cells sodium butyrateHDACihuman LS174T cells
Gene expression profile of ATF6a and ATF6b overexpression in LS174T cells sodium butyrateHDACiLS174T cells
Expression data from HT-29, a human colonic epithelial cell line sodium butyrate HDACiHT-29; a human colonic epithelial cell line
Expression profiling of host genes altered after chemical-induced recurrent Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells sodium butyrateHDACiNA cells; NA-P10/TS-MG and NA-P1/mock23024765
Effect of butyrate and DZNep on hESC HSF-6 sodium butyrate
3-Deazaneplanocin A
HDACi
HMTi
hESC HSF-622058289
ESC Exposed to Butyrate sodium butyrate HDACihESC BG02 and H119341625

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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