Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

read more

Pargyline

Category:HDMi
Cas Number:555-57-7
Molecular Formula:C11H13N
Molecular Weight:159.22762 g/mol
Smiles:CN(CC#C)CC1=CC=CC=C1
Description:Pargyline is a monoamine oxidase (MAO) inhibitor with antidepressant activity. Pargyline selectively inhibits MAO type B, an enzyme catalyzing the oxidative deamination and inactivation of certain catecholamines, such as norepinephrine and dopamine, within the presynaptic nerve terminals. By inhibiting the metabolism of these biogenic amines in the brain, pargyline increases their concentration and binding to postsynaptic receptors. Increased receptor stimulation may cause downregulation of central receptors which may attribute to pargyline's antidepressant effect.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (4.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
1008 PargylineMonoamine oxidase (Homo sapiens (Human))25600407
1009 PargylineMonoamine oxidase (Homo sapiens (Human))25600407
1010 PargylineMonoamine oxidase (Homo sapiens (Human))16137882
1011 PargylineMonoamine Oxidase Type B (MAO-B) (Rattus norvegicus (rat))19091581
1012 PargylineMonoamine oxidase (Rattus norvegicus (rat))19091581
1013 PargylineAdrenergic Alpha (RAT)17827
1014 PargylineAdrenergic Alpha (RAT)17827
1015 PargylineMonoamine oxidase (Homo sapiens (Human))19321235
1016 PargylineMonoamine oxidase (Homo sapiens (Human))23454517
1017 PargylineMonoamine oxidase (Homo sapiens (Human))25542589
1018 PargylineMonoamine oxidase (Homo sapiens (Human))25600407
1019 PargylineAldehyde dehydrogenase (Rattus norvegicus)
1020 PargylineAldehyde dehydrogenase, cytosolic 1 (Rattus norvegicus)
1021 PargylineMonoamine oxidase (Rattus norvegicus (rat))19091581
1022 PargylineMonoamine Oxidase Type B (MAO-B) (Rattus norvegicus (rat))18980841
1023 PargylineMonoamine Oxidase Type B (MAO-B) (Rattus norvegicus (rat))19091581
1024 PargylineMonoamine oxidase (Rattus norvegicus (rat))18980841
1025 PargylineMonoamine oxidase (Rattus norvegicus (rat))17611112
1026 PargylineMonoamine Oxidase Type B (MAO-B) (Rattus norvegicus (rat))17611112

Disease list

ConditionsDrug NameStatusNct NumberPhases
breast cancerPargyline
Suberoylanilide hydroxamic acid
Preclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
RNA expression in MDA-MB-231 cells treated for 24h with SAHA, Pargyline, or both [HG-U133A_2] Pargyline
Suberoylanilide hydroxamic acid
HDMi
HDACi
human breast cancer cells (MDA-MB-231)21452019
23354309

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

pix

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

Copyright

©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

吉ICP备16005872号