Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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clorgyline

Category:HDMi
Cas Number:17780-72-2
Molecular Formula:C13H15Cl2NO
Molecular Weight:272.1703 g/mol
Smiles:CN(CCCOC1=C(C=C(C=C1)Cl)Cl)CC#C
Description:Clorgyline is an antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (6.0KB)

Target list

Total Page:5 Page   of 5

Disease list

ConditionsDrug NameStatusNct NumberPhases
colon cancer5-Azacytidine
clorgyline
Preclinical study
healthyclorgylinePreclinical study
high grade prostate cancerclorgylinePreclinical study
bladder cance
leukemia
colon cancer
5-Aza-2'-deoxycytidine
clorgyline
Preclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes (methylation) 5-Aza-2'-deoxycytidine
clorgyline
DNMTi
HDMi
human bladder cancer cell line (T-24); human leukemia cell line (HL60); human colon cancer cell line (HCT116)24040395
Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes 5-Azacytidine
clorgyline
DNMTi
HDMi
human cancer cells (T24 ,HCT116 and HL-60 )24040395
Clorgyline treatment of VCaP cells clorgylineHDMiVCaP cells20204405
Effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells clorgylineHDMihigh grade prostate cancer cells19691856

Complex list

PDBIdDrug NameTargetmethodPubmedId
2BXR ClorgylineAMINE OXIDASE [FLAVIN-CONTAINING] A (Homo sapiens)X-RAY DIFFRACTION16129825
2BXS ClorgylineAMINE OXIDASE [FLAVIN-CONTAINING] A (Homo sapiens)X-RAY DIFFRACTION16129825
1O5W ClorgylineAmine oxidase [flavin-containing] A (Rattus norvegicus)X-RAY DIFFRACTION15050826

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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