Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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bizine

Category:HDMi
Cas Number:N.A.
Molecular Formula:C18H24ClN3O
Molecular Weight:333.8556 g/mol
Smiles:C1=CC=C(C=C1)CCCC(=O)NC2=CC=C(C=C2)CCNN.Cl
Description:Bizine containing a phenyl-butyrylamide appendage was shown to be a potent LSD1 inhibitor in vitro and was selective versus monoamine oxidases A/B and the LSD1 homolog, LSD2.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (7.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex

Disease list

ConditionsDrug NameStatusNct NumberPhases
prostate cancerbizinePreclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
A Selective Phenelzine Analog Inhibitor of Histone Demethylase LSD1 bizineHDMihuman LNCaP cells24707965

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

Copyright

©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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