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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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GSK-J4

Category:HDMi
Cas Number:1373423-53-0
Molecular Formula:C24H27N5O2
Molecular Weight:417.50348 g/mol
Smiles:CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=
CC=CC=N4
Description:GSK-J4 HCl is a kind of cell permeability GSK J1 precursor drugs, is the first selective H3K27histone demethylaseJMJD3 and UTX inhibitors, cell free trials for 60 nM IC50, inhibit enzyme activity JMJ family demethylation.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (8.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex

Disease list

ConditionsDrug NameStatusNct NumberPhases
Multiple MyelomaGSK-J4Preclinical study
ALLGSK-J4Preclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Activation of the Integrated Stress Response by a Jumonji Histone Demethylase Inhibitor Induces Pro-Apoptotic Metabolic Reprogramming in Multiple Myeloma GSK-J4HDMiMultiple Myeloma patients
Gene expression in TAL1-driven T-cell ALL in response to TAL1-KD, UTX-KD, and GSKJ4 treatment GSK-J4HDMiTAL1-driven T-cell ALL26944678

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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