Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

read more

epigallocatechin-3-gallate

Category:DNMTi
Cas Number:989-51-5
Molecular Formula:C22H18O11
Molecular Weight:458.37172 g/mol
Smiles:C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)
OC(=O)C4=CC(=C(C(=C4)O)O)O
Description:Epigallocatechin Gallate is a phenolic antioxidant found in a number of plants such as green and black tea. It inhibits cellular oxidation and prevents free radical damage to cells. It is under study as a potential cancer chemopreventive agent. (NCI)
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (8.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
3 epigallocatechin-3-gallateEnoyl-acyl-carrier protein reductase (Plasmodium falciparum)17263522
4 epigallocatechin-3-gallateCpG DNA methylase (Spiroplasma sp. (strain MQ-1))22854677
5 epigallocatechin-3-gallateEnoyl-acyl-carrier protein reductase (Plasmodium falciparum)17263522
6 epigallocatechin-3-gallateEnoyl-acyl-carrier protein reductase (Plasmodium falciparum)17263522
7 epigallocatechin-3-gallateDual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (RAT)12534346
8 epigallocatechin-3-gallateTyrosine-protein kinase Met (Homo sapiens (Human))19839593
9 epigallocatechin-3-gallateEnoyl-ACP Reductase (FabI) (Escherichia coli)17263522
10 epigallocatechin-3-gallateEnoyl-acyl-carrier protein reductase (Plasmodium falciparum)17263522
11 epigallocatechin-3-gallateSqualene monooxygenase (Rattus norvegicus)11520216
12 epigallocatechin-3-gallateMatrix metalloproteinase 7 (Homo sapiens (Human))19524436
13 epigallocatechin-3-gallate72 kDa type IV collagenase (homo sapiens (human))19524436
14 epigallocatechin-3-gallateMatrix metalloproteinase 14 (Homo sapiens)19524436
15 epigallocatechin-3-gallateTyrosine-protein kinase Met (Homo sapiens (Human))19839593
16 epigallocatechin-3-gallateLeukocyte elastase (Homo sapiens (Human))20004577
17 epigallocatechin-3-gallatePOsterior Segregation family member (pos-1) (Caenorhabditis elegans)
18 epigallocatechin-3-gallateRecName: Full=Zinc finger protein mex-5 (Caenorhabditis elegans)
19 epigallocatechin-3-gallateMAP kinase p38 (Homo sapiens (human))21080642
20 epigallocatechin-3-gallateAlpha-(1,3)-fucosyltransferase VII (HUMAN)15081893
21 epigallocatechin-3-gallateAlpha-(1,3)-fucosyltransferase VII (HUMAN)15081893
22 epigallocatechin-3-gallateAlpha-(1,3)-fucosyltransferase IV (HUMAN)15081893
Total Page:3 Page   of 3

Disease list

ConditionsDrug NameStatusNct NumberPhases
obeseepigallocatechin-3-gallate
Resveratrol
Preclinical study
healthy5-Aza-2'-deoxycytidine
epigallocatechin-3-gallate
Preclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Gene expression profiles of ovarian cancer cell lines in the presence and absence of a DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine
epigallocatechin-3-gallate
DNMTihuman regulatory T cells 24476360
Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial epigallocatechin-3-gallate
Resveratrol
DNMTi
HDACi
obese humans27194304

Complex list

PDBIdDrug NameTargetmethodPubmedId
4AWM epigallocatechin-3-gallatePOLYMERASE (Influenza A virus)X-RAY DIFFRACTION22876177
3OOB epigallocatechin-3-gallatePeptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Homo sapiens)X-RAY DIFFRACTION21750208
3NG5 epigallocatechin-3-gallateTransthyretin (Homo sapiens)X-RAY DIFFRACTION20565072
2KDH epigallocatechin-3-gallateTroponin C, slow skeletal and cardiac muscles (Homo sapiens)NMR19542563

About

pix

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

Copyright

©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

吉ICP备16005872号