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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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tranylcypromine

Category:HDMi
Cas Number:155-09-9
Molecular Formula:C9H11N
Molecular Weight:133.19034 g/mol
Smiles:C1C(C1N)C2=CC=CC=C2
Description:Tranylcypromine is a propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (11.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
1108 tranylcypromineMonoamine oxidase (Homo sapiens (Human))25600407
1109 tranylcypromineDopamine receptor D2 and D3 (Rattus norvegicus (Rat))24848155
1110 tranylcypromineLSD1/CoREST complex (Homo sapiens (Human))21382717
1111 tranylcypromineLSD1/CoREST complex (Homo sapiens (Human))21596573
1112 tranylcypromineCytochrome P450 2B6 (Homo sapiens (Human))19049427
1113 tranylcypromineCytochrome P450 2C19 (Homo sapiens (human))19049427
1114 tranylcypromineCytochrome P450 2C19 (Homo sapiens (human))21189020
1115 tranylcypromineCytochrome P450 2B6 (Homo sapiens (Human))21189020
1116 tranylcypromineCytochrome P450 2C19 (Homo sapiens (human))21384875
1117 tranylcypromineCytochrome P450 2B6 (Homo sapiens (Human))21384875
1118 tranylcypromineMonoamine oxidase (Homo sapiens (human))15537343
1119 tranylcypromineMonoamine oxidase (Homo sapiens (Human))15027872
1120 tranylcyprominetrace amine-associated receptor 1 (Homo sapiens)
1121 tranylcypromineguanine nucleotide-binding protein subunit alpha-15 (Homo sapiens)
1122 tranylcypromineguanine nucleotide-binding protein subunit alpha-15 (Homo sapiens)
1123 tranylcyprominetrace amine-associated receptor 1 (Homo sapiens)
1124 tranylcypromineLysine-specific histone demethylase 1B (Homo sapiens)24131029
1125 tranylcypromineLSD1/CoREST complex (Homo sapiens (Human))24131029
1126 tranylcypromineLSD1/CoREST complex (Homo sapiens (Human))24131029
1127 tranylcypromineLSD1/CoREST complex (Homo sapiens (Human))24131029
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Disease list

ConditionsDrug NameStatusNct NumberPhases
acute myeloid leukemiatranylcyprominePreclinical study
healthytranylcyprominePreclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia tranylcypromineHDMi human acute myeloid leukemia cell line ( HL-60 or TEX)22406747
Expression data of differentiated human erythroid cells with or without Tranylcypromine (TC) treatment tranylcypromineHDMi Primary human erythroid cells23416702

Complex list

PDBIdDrug NameTargetmethodPubmedId
3MDR tranylcypromineCholesterol 24-hydroxylase (Homo sapiens)X-RAY DIFFRACTION20667828

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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