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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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EPZ-6438

Category:HMTi
Cas Number:1403254-99-8
Molecular Formula:C34H44N4O4
Molecular Weight:572.73756 g/mol
Smiles:CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)
C4=CC=C(C=C4)CN5CCOCC5
Description:EPZ-6438 is an effective and selective EZH2 inhibitor, Ki is 2.5 nM, compared to a high selectivity for EZH1 35 times, compared to a high selectivity for 14 other HMT 4500 times.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (10.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex

Disease list

ConditionsDrug NameStatusNct NumberPhases
LymphomaEPZ-6438Preclinical study
lymphomaCPI360
EPZ-6438
GSK126
Preclinical study
non-Hodgkin lymphomaEPZ-6438Preclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Expression data from EZH2 inhibitor treated Non-Hodgkins Lymphoma cell lines EPZ-6438HMTihuman Lymphoma cell lines (WSU-DLCL2, SU-DHL6, Pfeiffer, and Karpas422)24563539
EZH2 inhibitor efficacy in non-Hodgkin lymphoma does not require suppression of H3K27 mono-methylation CPI360
EPZ-6438
GSK126
HMTihuman lymphoma cell line(Karpas422)25457180
EZH2 inhibitor efficacy in non-Hodgkin lymphoma does not require suppression of H3K27 mono-methylation EPZ-6438HMTinon-Hodgkin lymphoma KARPAS-422 cell line25457180

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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