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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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3-Deazaneplanocin A

Category:HMTi
Cas Number:102052-95-9
Molecular Formula:C12H14N4O3
Molecular Weight:262.26456 g/mol
Smiles:C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N
Description:3-Deazaneplanocin A is a drug which acts as both a S-adenosylhomocysteine synthesis inhibitor and also a histone methyltransferase EZH2 inhibitor. Studies have shown that it has in vitro against a variety of different tumor cell lines. In studies on mice, 3-deazaneplanocin A was also found to be effective for the treatment of Ebola virus disease, apparently interfering with the Ebola viruses ability to block interferon production which usually allows it to evade immune responses.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (6.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex

Disease list

ConditionsDrug NameStatusNct NumberPhases
breast cancer5-Azacytidine
Trichostatin A
3-Deazaneplanocin A
Preclinical study
healthysodium butyrate
3-Deazaneplanocin A
Preclinical study
small cell lung cancer (SCLC)3-Deazaneplanocin APreclinical study
healthy3-Deazaneplanocin APreclinical study
healthy3-Deazaneplanocin APreclinical study
glioblastoma multiforme (GBM)cancer3-Deazaneplanocin APreclinical study
breast cancer3-Deazaneplanocin A
5-Aza-2'-deoxycytidine
Preclinical study
breast cancer3-Deazaneplanocin A
5-Aza-2'-deoxycytidine
Preclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Combinatorial pharmacological approaches target EZH2-mediated gene repression in breast cancer cells 5-Azacytidine
Trichostatin A
3-Deazaneplanocin A
DNMTi
HDACi
HMTi
human breast cancer cells (MCF-7)19934278
Effect of butyrate and DZNep on hESC HSF-6 sodium butyrate
3-Deazaneplanocin A
HDACi
HMTi
hESC HSF-622058289
Gene repression with H3K27me3 modification in human small cell lung cancer 3-Deazaneplanocin AHMTiclinical SCLC samples; normal tissue samples; small cell lung cancer (SCLC) cell lines; normal small airway epithelial cell (SAEC)?23714854
Determinants of sensitivity to DZNep induced apoptosis in multiple myeloma cells 3-Deazaneplanocin AHMTiH929 cells21720561
DMSO control and DZNep treated MOLM-14 cells 3-Deazaneplanocin AHMTiMOLM-14 cells?21734239
DZNep-treated glioblastoma multiforme cancer stem cells 3-Deazaneplanocin AHMTiglioblastoma multiforme (GBM)cancer stem cells19934320
Effects of DZNep and 5-Aza-CdR on gene expression in MCF7 cells 3-Deazaneplanocin A
5-Aza-2'-deoxycytidine
HMTi
DNMTi
MCF7 cells19509260
Effects of DZNep and 5-Aza-CdR on gene expression in MCF7 cells after 72 h treatment 3-Deazaneplanocin A
5-Aza-2'-deoxycytidine
HMTi
DNMTi
MCF7 cells19509260

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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