Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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Zebularine

Category:DNMTi
Cas Number:3690-10-6
Molecular Formula:C9H12N2O5
Molecular Weight:228.20198 g/mol
Smiles:C1=CN(C(=O)N=C1)C2C(C(C(O2)CO)O)O
Description:Zebularine is a chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (5.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex

Disease list

ConditionsDrug NameStatusNct NumberPhases
CholangiocarcinomaZebularinePreclinical study
renal cell carcinomaZebularine Preclinical study
prostate cancerZebularinePreclinical study
hepatocellular carcinomaZebularinePreclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
DNA Methyltransferase Inhibitor Zebularine Induces Human Cholangiocarcinoma Cell Death through Alteration of DNA Methylation Status Zebularine DNMTiHuman Cholangiocarcinoma Cell lines (TFK1 and HuCCT1)25799509
Treatment of renal cell carcinoma cell line A-498 with zebularine Zebularine DNMTihuman renal cell carcinoma cell line (A-498)
Treatment of prostate cancer cell lines DU-145 and LNCaP with zebularine Zebularine DNMTihuman prostate cancer cell lines (DU-145 and LNCaP)
DNA methyltransferase inhibitor zebularine inhibits human hepatic carcinoma cells proliferation and induces apoptosis. Zebularine DNMTiHuman hepatocellular carcinoma cell line (HepG2)23320119

Complex list

PDBIdDrug NameTargetmethodPubmedId
4PD7 ZebularineNupC family protein (Vibrio cholerae)X-RAY DIFFRACTION25082345

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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