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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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CPI203

Category:PAHi
Cas Number:1446144-04-2
Molecular Formula:C18H18ClN5OS
Molecular Weight:399.89712 g/mol
Smiles:CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)N)C4=CC=C(C=C4)Cl)C
Description:CPI203 from in vitro and the cell inhibition BRD4, without affecting the BRD4 kinase activity in vitro.CPI203 showed in all 9 MCL cell line cell growth inhibition, GI50 range of 0.06 to 0.71 microns, and has low toxicity in the normal PBMCs of healthy volunteers.In addition, lenalidomide and CPI203 to IRF4 targets and MYC, effective activation of bortezomib resistance MCL cell programmed cell death.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (7.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex

Disease list

ConditionsDrug NameStatusNct NumberPhases
NeuroblastomaCPI203Preclinical study
multiple myelomaCPI203Preclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
The apoptotic network and expression of BH3-containing proteins predict phenotypic response to BET bromodomain inhibitors CPI203PAHiNeuroblastoma BE(2)-C and Kelly cells26759243
Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma CPI203 PAHiLP-1/MYC cell line26731516

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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