Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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RVX-208

Category:PAHi
Cas Number:1044870-39-4
Molecular Formula:C20H22N2O5
Molecular Weight:370.39908 g/mol
Smiles:CC1=CC(=CC(=C1OCCO)C)C2=NC(=O)C3=C(C=C(C=C3N2)OC)OC
Description:RVX-208 is an orally available small molecule created by Resverlogix Corp.that is being evaluated in clinical trials for the treatment of atherosclerosis and associated cardiovascular disease(CVD).In two phase II clinical trials in patients with established CVD, RVX-208 increased HDL-cholesterol(HDL-c) and apolipoprotein A-I (ApoA-I) levels, as well as decreased the incidence of major adverse cardiac events (MACE).Reduction of MACE was accentuated in patients with diabetes mellitus.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (7.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex

Disease list

ConditionsDrug NameStatusNct NumberPhases
hepatocellular carcinomaJQ1
RVX-208
Preclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Effect of BET inhibitors (JQ1 and RVX-208) on gene expression in HepG2 cells JQ1
RVX-208
PAHiHepG2 Cells 24248379

Complex list

PDBIdDrug NameTargetmethodPubmedId
4J1P RVX-208Bromodomain containing 2, isoform CRA_a (Homo sapiens)X-RAY DIFFRACTION24391744
4J3I RVX-208Bromodomain-containing protein 4 (Homo sapiens)X-RAY DIFFRACTION24391744
4MR5 RVX-208Bromodomain-containing protein 2 (Homo sapiens)X-RAY DIFFRACTION24248379
4MR4 RVX-208Bromodomain-containing protein 4 (Homo sapiens)X-RAY DIFFRACTION24248379
4MR6 RVX-208Bromodomain-containing protein 2 (Homo sapiens)X-RAY DIFFRACTION24248379
4MR3 RVX-208Bromodomain-containing protein 4 (Homo sapiens)X-RAY DIFFRACTION24248379

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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