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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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UNC669

Category:PMHi
Cas Number:1314241-44-5
Molecular Formula:C15H20BrN3O
Molecular Weight:338.2428 g/mol
Smiles:C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=CN=C3)Br
Description:UNC669 is a potent selectivity of MBT (malignant brain tumor) inhibitor, IC50 of 5 microns, for its L3MBTL1 selectivity than L3MBTL3 and L3MBTL4 5 times, respectively, 11 times.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (7.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
1348 UNC669Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) (Homo sapiens (Human))21417280
1349 UNC669Chromobox protein homolog 7 (CBX7) (Homo sapiens (Human))24040942
1350 UNC669Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) (Homo sapiens (Human))21417280
1351 UNC669Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) (Homo sapiens (Human))21417280
1352 UNC669Lethal(3)malignant brain tumor-like protein 4 (Homo sapiens)21417280
1353 UNC669MBT domain-containing protein 1 (MBTD1) (Homo sapiens (Human))24040942
1354 UNC669Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) (Homo sapiens (Human))24040942
1355 UNC669Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) (Homo sapiens (Human))24040942
1356 UNC669Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) (Homo sapiens (Human))24040942
1357 UNC669Scm-like with four MBT domains protein 1 (Homo sapiens)24040942
1358 UNC669Lethal(3)malignant brain tumor-like protein 4 (Homo sapiens)24040942
1359 UNC669Histone demethylase JARID1A (Homo sapiens (Human))24040942
1360 UNC669PHD finger protein 23 (PHF23) (Homo sapiens (Human))24040942
1361 UNC669E3 ubiquitin-protein ligase (UHRF1) (Homo sapiens (Human))24040942
1362 UNC669Tumor suppressor p53-binding protein 1 (Homo sapiens)24040942
1363 UNC669Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) (Homo sapiens (Human))24040942

Disease list

ConditionsDrug NameStatusNct NumberPhases

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID

Complex list

PDBIdDrug NameTargetmethodPubmedId
3P8H UNC669Lethal(3)malignant brain tumor-like protein(Homo sapiens)X-RAY DIFFRACTION21417280

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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