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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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UNC1215

Category:PMHi
Cas Number:1415800-43-9
Molecular Formula:C32H43N5O2
Molecular Weight:529.71612 g/mol
Smiles:C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)C(=O)
N4CCC(CC4)N5CCCC5)NC6=CC=CC=C6
Description:UNC1215 combined with L3MBTL3, competitive replacement peptides containing single or 2 methyl lysine.This kind of probe to high selectivity for other members of the family of human MBT 50 times.Applied to L3MBTL3 UNC1215 compared to used for L3MBTL1 selective about 75 times higher.UNC1215 concentration up to 30 microns, the series of UHRF1 Tudor domain, CBX7 chromatin domain, and active JARID1A PHD domain has no effect.X-ray crystallography shows UNC1215 and L3MBTL3 between a unique and diverse interactive mode.UNC1215 effects on cells is non-toxic, through MBT domain Kme set milestones in combination with pockets, combining to L3MBTL3 directly.UNC1215 increase the GFP - L3MBTL3 fusion protein cell mobility, and point mutations, interfere with GFP - L3MBTL3 phenotype simulation Kme set milestones in combination with functions, influence UNC1215 positioning.UNC1215 used to reveal a new kind of Kme set milestones dependent L3MBTL3, interaction with BCLAF1 BCLAF1 is a kind of with DNA damage repair and apoptosis is closely related to the proteins.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (11.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
1364 UNC1215Scm-like with four MBT domains protein 1 (Homo sapiens)24040942
1365 UNC1215Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) (Homo sapiens (Human))24040942
1366 UNC1215PHD finger protein 23 (PHF23) (Homo sapiens (Human))24040942
1367 UNC1215Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) (Homo sapiens (Human))24040942
1368 UNC1215Lethal(3)malignant brain tumor-like protein 4 (Homo sapiens)24040942
1369 UNC1215Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) (Homo sapiens (Human))24040942
1370 UNC1215MBT domain-containing protein 1 (MBTD1) (Homo sapiens (Human))24040942
1371 UNC1215Histone demethylase JARID1A (Homo sapiens (Human))24040942
1372 UNC1215Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) (Homo sapiens (Human))24040942
1373 UNC1215E3 ubiquitin-protein ligase (UHRF1) (Homo sapiens (Human))24040942
1374 UNC1215Tumor suppressor p53-binding protein 1 (Homo sapiens)24040942
1375 UNC1215Chromobox protein homolog 7 (CBX7) (Homo sapiens (Human))24040942
1376 UNC1215Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) (Homo sapiens (Human))24040942

Disease list

ConditionsDrug NameStatusNct NumberPhases

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID

Complex list

PDBIdDrug NameTargetmethodPubmedId
3UWN UNC1215Lethal(3)malignant brain tumor-like protein 1 (Homo sapiens)X-RAY DIFFRACTION
4FL6 UNC1215Lethal(3)malignant brain tumor-like protein 3 (Homo sapiens)X-RAY DIFFRACTION

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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