Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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hydralazine

Category:DNMTi
Cas Number:86-54-4
Molecular Formula:C8H8N4
Molecular Weight:160.17592 g/mol
Smiles:C1=CC=C2C(=C1)C=NN=C2NN
Description:HDAC Inhibitor ITF2357 is an orally bioavailable hydroxymate inhibitor of histone deacetylase (HDAC) with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. Givinostat inhibits class I and class II HDACs, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. At low, nonapoptotic concentrations, this agent inhibits the production of pro-inflammatory cytokines such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-6 and interferon-gamma. Givinostat has also been shown to activate the intrinsic apoptotic pathway, inducing apoptosis in hepatoma cells and leukemic cells. This agent may also exhibit anti-angiogenic activity, inhibiting the production of angiogenic factors such as IL-6 and vascular endothelial cell growth factor (VEGF) by bone marrow stromal cells.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (4.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
54 hydralazineAdrenergic Alpha (RAT)17827
55 hydralazineAdrenergic Alpha (RAT)17827
56 hydralazine8-Oxoguanine DNA glycosylase-1 (OGG1) (Homo sapiens (Human))26218629

Disease list

ConditionsDrug NameStatusNct NumberPhases
hypertensionhydralazineCompletedapproved(NDA 008303)
Cervical cancerHydralazine
magnesium valproate
CompletedNCT00404326Phase 2
Locally advanced breast cancerHydralazine
magnesium valproate
TerminatedNCT00395655Phase 2
Refractory solid tumorsHydralazine
magnesium valproate
CompletedNCT00404508Phase 2
carcinoma of the cervixhydralazine
magnesium valproate
Preclinical study
primary breast cancerhydralazine
magnesium valproate
Preclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Epigenetic therapy with hydralazine and magnesium valproate added to chemoradiation in cervical carcinoma. hydralazine
magnesium valproate
DNMTi
HDACi
Previously untreated patients with histological diagnosis of carcinoma of the cervix and FIGO
Gene Expression Profiles of Epigenetic treatment in primary breast cancer. hydralazine
magnesium valproate
DNMTi
HDACi
The patients with primary breast cancer17183730

Complex list

PDBIdDrug NameTargetmethodPubmedId
3LTW hydralazineArylamine N-acetyltransferase Nat (Mycobacterium marinum)X-RAY DIFFRACTION21203950

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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