Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

read more

carbamazepine

Category:HDACi
Cas Number:298-46-4
Molecular Formula:C15H12N2O
Molecular Weight:236.26858 g/mol
Smiles:C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N
Description:Carbamazepine is an Anti-epileptic Agent and Mood Stabilizer. The mechanism of action of carbamazepine is as a Cytochrome P450 3A4 Inducer and Cytochrome P450 1A2 Inducer and Cytochrome P450 2B6 Inducer and Cytochrome P450 2C9 Inducer and Cytochrome P450 2C19 Inducer. The physiologic effect of carbamazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (5.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
1377 carbamazepineCytochrome P450 3A (Homo sapiens (human))
1378 carbamazepineCytochrome P450 3A (Homo sapiens (human))
1379 carbamazepineVoltage-gated sodium channel subunit alpha Nav1.7 (NaV1.7) (Homo sapiens (Human))18243692
1380 carbamazepineP2X purinoceptor 4 (HUMAN)24411477
1381 carbamazepineVoltage-gated potassium channel (Homo sapiens (human))21185626
1382 carbamazepineBile salt export pump (BSEP) (Homo sapiens (Human))21965623
1383 carbamazepineHTR3A (Mus musculus (house mouse))9686407
1384 carbamazepineDopamine D1 receptor (Homo sapiens (Human))9686407
1385 carbamazepineDRD2 (HUMAN)9686407
1386 carbamazepineHistamine H1 receptor (Homo sapiens (human))6146381
1387 carbamazepineSodium channel alpha subunit (Homo sapiens)14998340
1388 carbamazepinePrion protein (Homo sapiens)12904059
1389 carbamazepineSerotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat))9686407
1390 carbamazepineHTR2A (RAT)9686407
1391 carbamazepineDopamine D2 receptor and serotonin 1a receptor (Homo sapiens (human))9686407
1392 carbamazepineGlutamate-NMDA-MK801 (RAT)10604951

Disease list

ConditionsDrug NameStatusNct NumberPhases
healthyvalproic acid
carbamazepine
Preclinical study

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Human embryonic stem cell based neuro-developmental toxicity assay: response to valproic acid and carbamazepine exposure valproic acid
carbamazepine
HDACihuman embryonic stem cell (hESC)25979313

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

pix

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

Copyright

©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

吉ICP备16005872号