HEDD

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

Curcumin

Category:	HATi
Cas Number:	458-37-7
Molecular Formula:	C₂₁H₂₀O₆
Molecular Weight:	368.3799 g/mol
Smiles:	COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
Description:	Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive-oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer. (NCI04)
synonyms:	curcumin Diferuloylmethane Natural yellow 3 458-37-7 Turmeric yellow Turmeric Curcumin I Gelbwurz Curcuma Haldar Souchet Haidr Halad Halud Indian saffron Kacha haldi Yellow Ginger Terra Merita Yellow Root Safran d'Inde Yo-Kin Orange Root Hydrastis Indian turmeric Tumeric yellow Yellow puccoon C.I. Natural Yellow 3 Golden seal Diferaloylmethane Kurkumin [Czech] Cucurmin Curcumine CI Natural Yellow 3 Turmeric extract Oils, curcuma Zlut prirodni 3 [Czech] C.I. 75300 Diferulylmethane Curcuma oil Turmeric oil (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione Oil of turmeric Tumeric oleoresin Turmeric oleoresin Curcuma longa oils Turmeric, oleoresin Turmeric (>98% curcurmin) 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione 1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione Turmeric oleoresin (79%-85% curcumin) E 100 NSC32982 NSC 32982 CHEMBL140 UNII-IT942ZTH98 Curcuma oil (Curcuma longa) Curcurmin FEMA No. 3085 FEMA No. 3086 MLS000069631 CCRIS 3257 CCRIS 5804 CHEBI:3962 1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione HSDB 4334 Turmeric oil (Curcuma longa L.) VFLDPWHFBUODDF-FCXRPNKRSA-N NCI-C61325 (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione EINECS 207-280-5 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)- MFCD00008365 NSC-32982 NSC687842 NSC 687842 BRN 2306965 NCGC00017159-05 CI 75300 SMR000058237 DSSTox_CID_1421 (1E,6E)-1,7-bis(4-hydroxy-3-methoxy-phenyl)hepta-1,6-diene-3,5-dione 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)- DSSTox_RID_78861 DSSTox_GSID_31077 8024-37-1 2,7-Nonadiene-4,6-dione, 1,9-bis(4-hydroxy-3-methoxyphenyl)- (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (1E,6E)-1,7-bis[4-hydroxy-3-(methyloxy)phenyl]hepta-1,6-diene-3,5-dione CAS-458-37-7 curouma Kurkumin kachs haldi 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)- safra d'inde Natural Yellow3 Zlut prirodni 3 Turmeric root oil Tu rmeric root oil 98% curcurmin) trans,trans-Curcumin Curcuma longa l. oil Turmeric root oleoresin Curcuma longa l. oleoresin Curcuma longa l. root oil AC1LJ6T6 SCHEMBL8440 SCHEMBL8441 MLS001148449 BIDD:ER0479 Bio-0677 C1386_SIGMA C7727_SIGMA AC1Q46A0 cid_969516 GTPL7000 IT942ZTH98 Curcuma longa l. root oleoresin E 100 (Dye) DTXSID8031077 SCHEMBL13521974 BDBM29532 cid_5281767 HMDB02269 1,5-Di(vanillyliden)acetylaceton cMAP_000052 HMS2233K04 HMS3649K06 ZINC899824 HY-N0005 1,5-Divanillyliden-2,4-pentandion Tox21_110803 Tox21_111505 Tox21_201116 BBL027711 BDBM50067040 CC0179 CCG-36020 CCG-36107 LS-125 SBB006495 STL371943 Turmeric extract (Curcuma longa L.) ZINC00899824 AKOS001305497 BCP9000557 CS-1490 CS-O-01231 LS-2189 NSC-687842 NCGC00017159-04 NCGC00017159-06 NCGC00017159-07 NCGC00017159-09 NCGC00017159-10 NCGC00017159-11 NCGC00017159-12 NCGC00023332-03 NCGC00023332-04 NCGC00023332-05 NCGC00258668-01 AC-24238 AK316302 AN-23454 BC678109 BT000615 LP076187 M212 OR070532 OR226563 SC-17381 ST055629 BCP0726000035 DB-002681 KB-251224 TR-032605 WLN: 1OR BQ E1U1V1V1U1R DQ CO1 C2302 FT-0607020 FT-0665233 FT-0688157 N1839 1,3-Di(3-methoxy-4-hydroxystyryl)propanedial 1790-EP2305629A1 1790-EP2308861A1 J10108 W-5038 4-08-00-03697 (Beilstein Handbook Reference) 1,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)- CU-01000001305-2 I06-0010 I06-2497 BRD-K07572174-001-02-2 BRD-K07572174-001-19-6 BRD-K07572174-001-22-0 I14-19358 CURCUMIN (SEE ALSO TUMERIC, OLEORESIN (10105-J)) 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione 1,7-bis(4-hydroxy-3-methoxyphenyl)1,6-heptadiene-3,5-dione 1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione 1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione Curcumin, 95% (total curcuminoid content), from Turmeric rhizome ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) (1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-1,6-diene-3,5-dione (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione # (1E,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione (1Z,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, (E,E)- 1,7-DI(4-HYDROXY-3-METHOXYPHENYL)HEPTA-1,6-DIENE-3,5-DIONE 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one 5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one Curcumin; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione PREVENTION 4 (CURCUMIN) (SEE ALSO TUMERIC, OLEORESIN (10105-J)) TURMERIC, OLEORESIN (CURCUMIN) (SEE ALSO CURCURMIN (458-37-7)) (1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one 15845-47-3 33171-04-9 73729-23-4 79257-48-0 91884-86-5
Structure:
3D Conformer:	3D View
Downlaod:	Structure File Download (7.0KB)

Target list

Id	Drug Name	Target	PubmedId	Co-crystal Complex
1426	Curcumin	Prostaglandin E synthase (Homo sapiens (Human))	24406103
1427	Curcumin	Beta lactamase (Pseudomonas aeruginosa)
1428	Curcumin	toll-like receptor 9 (Homo sapiens)
1429	Curcumin	perilipin-1 (Homo sapiens)
1430	Curcumin	perilipin-5 (Homo sapiens)
1431	Curcumin	Integrase (Human immunodeficiency virus (HIV-1))
1432	Curcumin	Matrix metalloproteinase (1 and 13) (Homo sapiens (human))
1433	Curcumin	Phospholipase A2 (Homo sapiens (Human))	24406103
1434	Curcumin	Alpi (Rattus norvegicus (Rat))
1435	Curcumin	TPA: Essential protein of the mitochondrial intermembrane space (Saccharomyces cerevisiae S288c)
1436	Curcumin	Cyclooxygenase-1 (COX-1) (Ovis aries (Sheep))	24406103
1437	Curcumin	Lipoxygenase (LOX) (Glycine max (Soybean))	24406103
1438	Curcumin	hypothetical protein SA1422 (Staphylococcus aureus subsp. aureus N315)
1439	Curcumin	Cyclooxygenase (Homo sapiens (human))	24406103
1440	Curcumin	Alkaline phosphatase, tissue-nonspecific isozyme (Homo sapiens)
1441	Curcumin	Alkaline phosphatase placental-like (Homo sapiens)
1442	Curcumin	Intestinal alkaline phosphatase (Homo sapiens)
1443	Curcumin	Genome polyprotein (West Nile virus)
1444	Curcumin	Serotonin Receptor 4 (Homo sapiens)	19334715

Disease list

Conditions	Drug Name	Status	Nct Number	Phases
Healthy	Curcumin	Completed	NCT00895167	Phase 1
Inflammatory bowel disease\|ulcerative colitis\|Crohn’s disease	Curcumin	Completed	NCT00889161	Phase 1
Colorectal cancer	Curcumin	Completed	NCT00027495	Phase 1
Alzheimer’s disease	Curcumin	Completed	NCT00164749	Phase 1 and 2
Breast cancer	Curcumin	Completed	NCT01042938	Phase 2
Alzheimer’s disease	Curcumin C3 complex	Completed	NCT00099710	Phase 2
Pancreatic cancer	Curcumin gemcitabine	Completed	NCT00192842	Phase 2
Familial adenomatous polyposis	Curcumin	Terminated	NCT00248053	Phase 2
Psoriasis	Curcumin C3 complex	Completed	NCT00235625	Phase 2
Oral lichen planus	Curcuminoids	Completed	NCT00525421	Phase 2
Irritable bowel syndrome	Curcumin	Completed	NCT00779493	Phase 4
Atopic asthma	Curcumin	Completed	NCT01179256	PHN.A
Multiple myeloma	Curcumin bioperine	Completed	NCT00113841	PHN.A
Healthy	Curcumin	Completed	NCT00181662	PHN.A
Chronic obstructive pulmonary disease	Curcumin bioperine	Completed	NCT01514266	PHN.A
Mild cognitive impairment	Curcumin bioperine	Completed	NCT00595582	PHN.A
Major depressive disorder	Curcumin fluoxetine	Completed	NCT01022632	PHN.A
Aberrant crypt foci	Curcumin	Terminated	NCT00176618	PHN.A
Healthy no evidence of disease	Curcumin	Completed	NCT00768118	PHN.A
Colorectal cancer	Curcumin quercitin sulindac	Terminated	NCT00003365	PHN.A

High-throughoutput Dataset

Title	Drug Name	Category	Sample type	PMID
Impact of curcumin on human monocytes (U937 cells) exposed to oxidative stress	curcumin	HATi	Human PMA-differentiated U937 cells	18421084
Curcumin Effectively Depletes Hepatic Cancer Stem-Like Cells	curcumin	HATi	human hepatoma cell lines	25937435
Genome-wide expression profiling of 30 uM curcumin treatment of immortalized prostate fibroblasts (PShTert-AR)	curcumin	HATi	PShTert-AR cells
Y79 retinoblastoma cells: control vs. curcumin treated	curcumin	HATi	human Y79 retinoblastoma cell line
Gene expression analysis study in curcumin treated and control Y79 cells	curcumin	HATi	human Y79 retinoblastoma cell line	22489823
Expression data of HL-60 leukemia cells after treatment with Curcumin and TCDD	curcumin	HATi	HL-60 cells
Impact of curcumin on human monocytes (U937 cells) exposed to oxidative stress	curcumin	HATi	Human PMA-differentiated U937 cells	18421014

Complex list

PDBId

Drug Name

Target

method

PubmedId

About

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.