Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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Curcumin

Category:HATi
Cas Number:458-37-7
Molecular Formula:C21H20O6
Molecular Weight:368.3799 g/mol
Smiles:COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
Description:Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive-oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer. (NCI04)
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (7.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
1426 CurcuminProstaglandin E synthase (Homo sapiens (Human))24406103
1427 CurcuminBeta lactamase (Pseudomonas aeruginosa)
1428 Curcumintoll-like receptor 9 (Homo sapiens)
1429 Curcuminperilipin-1 (Homo sapiens)
1430 Curcuminperilipin-5 (Homo sapiens)
1431 CurcuminIntegrase (Human immunodeficiency virus (HIV-1))
1432 CurcuminMatrix metalloproteinase (1 and 13) (Homo sapiens (human))
1433 CurcuminPhospholipase A2 (Homo sapiens (Human))24406103
1434 CurcuminAlpi (Rattus norvegicus (Rat))
1435 CurcuminTPA: Essential protein of the mitochondrial intermembrane space (Saccharomyces cerevisiae S288c)
1436 CurcuminCyclooxygenase-1 (COX-1) (Ovis aries (Sheep))24406103
1437 CurcuminLipoxygenase (LOX) (Glycine max (Soybean))24406103
1438 Curcuminhypothetical protein SA1422 (Staphylococcus aureus subsp. aureus N315)
1439 CurcuminCyclooxygenase (Homo sapiens (human))24406103
1440 CurcuminAlkaline phosphatase, tissue-nonspecific isozyme (Homo sapiens)
1441 CurcuminAlkaline phosphatase placental-like (Homo sapiens)
1442 CurcuminIntestinal alkaline phosphatase (Homo sapiens)
1443 CurcuminGenome polyprotein (West Nile virus)
1444 CurcuminSerotonin Receptor 4 (Homo sapiens)19334715

Disease list

ConditionsDrug NameStatusNct NumberPhases
HealthyCurcuminCompletedNCT00895167Phase 1
Inflammatory bowel disease|ulcerative colitis|Crohn’s diseaseCurcuminCompletedNCT00889161Phase 1
Colorectal cancerCurcuminCompletedNCT00027495Phase 1
Alzheimer’s diseaseCurcuminCompletedNCT00164749Phase 1 and 2
Breast cancerCurcuminCompletedNCT01042938Phase 2
Alzheimer’s diseaseCurcumin C3 complexCompletedNCT00099710Phase 2
Pancreatic cancerCurcumin
gemcitabine
CompletedNCT00192842Phase 2
Familial adenomatous polyposisCurcuminTerminatedNCT00248053Phase 2
PsoriasisCurcumin C3 complexCompletedNCT00235625Phase 2
Oral lichen planusCurcuminoidsCompletedNCT00525421Phase 2
Irritable bowel syndromeCurcuminCompletedNCT00779493Phase 4
Atopic asthmaCurcuminCompletedNCT01179256PHN.A
Multiple myelomaCurcumin
bioperine
CompletedNCT00113841PHN.A
HealthyCurcuminCompletedNCT00181662PHN.A
Chronic obstructive pulmonary diseaseCurcumin
bioperine
CompletedNCT01514266PHN.A
Mild cognitive impairmentCurcumin
bioperine
CompletedNCT00595582PHN.A
Major depressive disorderCurcumin
fluoxetine
CompletedNCT01022632PHN.A
Aberrant crypt fociCurcuminTerminatedNCT00176618PHN.A
Healthy
no evidence of disease
CurcuminCompletedNCT00768118PHN.A
Colorectal cancerCurcumin
quercitin
sulindac
TerminatedNCT00003365PHN.A
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High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Impact of curcumin on human monocytes (U937 cells) exposed to oxidative stress curcuminHATiHuman PMA-differentiated U937 cells18421084
Curcumin Effectively Depletes Hepatic Cancer Stem-Like Cells curcuminHATihuman hepatoma cell lines25937435
Genome-wide expression profiling of 30 uM curcumin treatment of immortalized prostate fibroblasts (PShTert-AR) curcuminHATiPShTert-AR cells
Y79 retinoblastoma cells: control vs. curcumin treated curcuminHATihuman Y79 retinoblastoma cell line
Gene expression analysis study in curcumin treated and control Y79 cells curcuminHATihuman Y79 retinoblastoma cell line22489823
Expression data of HL-60 leukemia cells after treatment with Curcumin and TCDD curcuminHATiHL-60 cells
Impact of curcumin on human monocytes (U937 cells) exposed to oxidative stress curcuminHATiHuman PMA-differentiated U937 cells18421014

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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