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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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Sodium phenylbutyrate

Category:HDACi
Cas Number:1716-12-7
Molecular Formula:C10H11NaO2
Molecular Weight:186.182909 g/mol
Smiles:C1=CC=C(C=C1)CCCC(=O)[O-].[Na+]
Description:Sodium phenylbutyrate is a salt of an aromatic fatty acid. The compound is used to treat urea cycle disorders, because its metabolites offer an alternative pathway to the urea cycle to allow excretion of excess nitrogen. Sodium phenylbutyrate is also a histone deacetylase inhibitor and chemical chaperone, leading respectively to research into its use as an anti-cancer agent and in protein misfolding diseases such as cystic fibrosis.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (4.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex

Disease list

ConditionsDrug NameStatusNct NumberPhases
Leukemia
MDSs
5-Azacytidine
sodium phenylbutyrate
CompletedNCT00004871Phase 1
Lymphoma
small intestine cancer
5-Azacytidine
sodium phenylbutyrate
CompletedNCT00005639Phase 1
Amyotrophic lateral sclerosisSodium phenylbutyrateCompletedNCT00107770Phase 1 2
Huntington’s diseaseSodium phenylbutyrateCompletedNCT00212316Phase 2
Hematologic and solid tumors5-Azacytidine
sodium phenylbutyrate
CompletedNCT00006019Phase 2
Thalassemia major5-Azacytidine
sodium phenylbutyrate
TerminatedNCT00007072Phase 2

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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