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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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Resveratrol

Category:HDACi
Cas Number:501-36-0
Molecular Formula:C14H12O3
Molecular Weight:228.24328 g/mol
Smiles:C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O
Description:Resveratrol is a phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-kappaB in a dose- and time-dependent manner. (NCI05)
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (6.0KB)

Target list

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Disease list

ConditionsDrug NameStatusNct NumberPhases
Colon cancerResveratrolCompletedNCT00256334Phase 1
Sports concussionResveratrolCompletedNCT01321151Phase 1
Neoplasms
colorectal cancer
ResveratrolCompletedNCT00920803Phase 1
Melanoma (skin)ResveratrolCompletedNCT00721877Phase 1
HealthyResveratrolCompletedNCT01640197Phase 1
Colorectal cancerResveratrolCompletedNCT00433576Phase 1
Unspecified adult solid tumorResveratrolCompletedNCT00098969Phase 1
Cardiovascular diseasesResveratrolCompletedNCT01449110Phase 2
Sedentary lifestyleResveratrolCompletedNCT01615445Phase 2
Multiple myelomaResveratrolTerminatedNCT00920556Phase 2
Chronic subclinic inflammationResveratrolCompletedNCT01492114Phase 3
HealthyResveratrol
midazolam
CompletedNCT01173640PHN.A
Cognitive and cerebral blood flowResveratrolCompletedNCT01010009PHN.A
Type 2 diabetes mellitusResveratrolCompletedNCT01038089PHN.A
HealthyResveratrolCompletedNCT01331382PHN.A
Metabolic syndrome
obesity
ResveratrolCompletedNCT01150955PHN.A
Obesity
metabolic syndrome
diabetes
ResveratrolCompletedNCT00823381PHN.A
ObesityResveratrolCompletedNCT00998504PHN.A
Cardiovascular diseaseResveratrolCompletedNCT01199549PHN.A
Cellulite (orange peel skin)ResveratrolTerminatedNCT01321268PHN.A
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High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2'-dC upon inhibition of ribonucleotide reductase-wide 5-Aza-2'-deoxycytidine
Resveratrol
DNMTi
HDACi
human myeloid leukemia cell lines26468331
Resveratrol action on A549 lung cancer cells ResveratrolHDACiA549 lung cancer cells18089832
Resveratrol-induced gene expression profiles in human prostate cancer cells ResveratrolHDACihuman prostate cancer cells15767336
Gene expression profiles of MCF7 cells treated with traditional Chinese medicine components ResveratrolHDACiMCF7 cells
Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity ResveratrolHDACihuman breast cancer cell lines27207652
Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial epigallocatechin-3-gallate
Resveratrol
DNMTi
HDACi
obese humans27194304
Trans-resveratrol induces a potential anti-lipogenic effect in lipopolysaccharide-stimulated enterocytes ResveratrolHDACiCaco-2 cells
Placebo-controlled, randomized clinical trial with repeated liver biopsies: Long-term resveratrol treatment has no clear therapeutic benefit in non-alcoholic fatty liver disease ResveratrolHDACi28 overweight patients with transaminasemia and histological NAFLD26784973
Hormetic shifting of redox environment by the ROS-producing polyphenol resveratrol protects cells from oxidative stress ResveratrolHDACineonatal normal human epidermal keratinocytes (NHEK)
Genome expression profiling identifies host-directed antimicrobial drugs against respiratory infection by nontypable Haemophilus influenzae ResveratrolHDACiA549 human type II pneumocyte cell line26416856
Whole cell mRNA expression profiling in control and complex I deficient patient fibroblasts incubated with DMSO, AICAR, chloramphenicol, and resveratrol ResveratrolHDACicontrol and complex I deficient patient fibroblast cell lines26369791
Anticancer effects of pycnogenol, catechin, epicatechin, taxifol and resveratrol on human fibrosarcoma cells ResveratrolHDACihuman fibrosarcoma cells (HT1080)25667456
25625225
Resveratrol prevents diet-induced arterial degeneration and stiffening in nonhuman primates ResveratrolHDACiMacaca mulatta24882067
Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on a high-fat, high-sugar diet. ResveratrolHDACiMacaca mulatta24093677
Effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men ResveratrolHDACihealthy obese men23958793
The influence of resveratrol on rheumatoid fibroblast-like synoviocytes based on a gene chip transcription analysis ResveratrolHDACirheumatoid arthritis FLS_patient
Transcriptomic effects of caloric restriction reflected in primate difference ResveratrolHDACipost-mortem brain, heart, and liver samples from 16 human, 16 chimpanzee and 4 rhesus macaque
Resveratrol supplementation does not improve metabolic function in non-obese women with normal glucose tolerance ResveratrolHDACinon-obese, postmenopausal women with normal glucose tolerance
Comparative transcriptomic profiling of peripheral blood mononuclear cells (PBMCs) isolated from patients in secondary prevention of CVD taking placebo, grape extract or resveratrol-enriched grape extract ResveratrolHDACiperipheral blood mononuclear cells (PBMCs) isolated from patients in secondary prevention of CVD23557933
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans ResveratrolHDACihealthy, obese men22055504
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Complex list

PDBIdDrug NameTargetmethodPubmedId
5BTR resveratrolNAD-dependent protein deacetylase sirtuin-1(Homo sapiens)X-RAY DIFFRACTION26109052
4QOJ resveratrolRibosyldihydronicotinamide dehydrogenase [quinone] (Homo sapiens)X-RAY DIFFRACTION
4QOH resveratrolRibosyldihydronicotinamide dehydrogenase [quinone] (Homo sapiens)X-RAY DIFFRACTION
4PP6 resveratrolEstrogen receptor (Homo sapiens)X-RAY DIFFRACTION24771768
3FTS resveratrolLeukotriene A-4 hydrolase (Homo sapiens)X-RAY DIFFRACTION19618939

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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