Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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dacinostat

Category:HDACi
Cas Number:404951-53-7
Molecular Formula:C22H25N3O3
Molecular Weight:379.4522 g/mol
Smiles:C1=CC=C2C(=C1)C(=CN2)CCN(CCO)CC3=CC=C(C=C3)C=CC(=O)NO
Description:LAQ824 (also known as NVP-LAQ824 or Dacinostat), a derivative of 4-aminomethylcinnamic ydroxamic acid, is a novel and potent inhibitor of histone deacetylase (HDAC) that inhibits the activity of HDAC with 50% inhibition concentration IC50 value of 0.03 μM.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (8.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
1565 dacinostatHistone deacetylase 3 (Homo sapiens (human))17956988
1566 dacinostatHistone deacetylase 4 (HDAC4) (Homo sapiens (Human))17956988
1567 dacinostatHistone deacetylase 4 (HDAC4) (Homo sapiens (Human))17956988
1568 dacinostatHistone deacetylase 4 (HDAC4) (Homo sapiens (Human))17956988
1569 dacinostatHistone deacetylase 1 (HDAC1) (Homo sapiens (human))18308563
1570 dacinostatHistone deacetylase 4 (HDAC4) (Homo sapiens (Human))17956988
1571 dacinostatHistone deacetylase 1 (HDAC1) (Homo sapiens (human))
1572 dacinostatHistone deacetylase 3 (Homo sapiens (human))18308563
1573 dacinostatHistone deacetylase 8 (Homo sapiens (human))
1574 dacinostatHistone deacetylase 4 (HDAC4) (Homo sapiens (Human))17956988
1575 dacinostatHistone Deacetylase 4 (HDAC4) Mutant (H976Y) (Homo sapiens (human))18308563
1576 dacinostatHistone deacetylase 5 (HDAC5) (Homo sapiens (Human))
1577 dacinostatHistone deacetylase (Homo sapiens (human))
1578 dacinostatHistone deacetylase 4 (HDAC4) (Homo sapiens (Human))
1579 dacinostatHistone deacetylase (Homo sapiens (human))
1580 dacinostatHistone deacetylase (Homo sapiens (human))
1581 dacinostatHistone deacetylase (HDAC1 and HDAC2) (Homo sapiens (human))17941625
1582 dacinostatHistone deacetylase 1 (HDAC1) (Homo sapiens (human))17941625
1583 dacinostatHistone deacetylase 1 (HDAC1) (Homo sapiens (human))19699639
1584 dacinostatHistone deacetylase 9 (HDAC9) (Homo sapiens (Human))
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Disease list

ConditionsDrug NameStatusNct NumberPhases

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID

Complex list

PDBIdDrug NameTargetmethodPubmedId

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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