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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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Droxinostat

Category:HDACi
Cas Number:99873-43-5
Molecular Formula:C11H14ClNO3
Molecular Weight:243.68676 g/mol
Smiles:CC1=C(C=CC(=C1)Cl)OCCCC(=O)NO
Description:Droxinostat is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (5.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
1605 Droxinostatprotein artemis isoform a (Homo sapiens)
1606 DroxinostatZinc aminopeptidase (Plasmodium falciparum (isolate FcB1 / Columbia))

Disease list

ConditionsDrug NameStatusNct NumberPhases

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID

Complex list

PDBIdDrug NameTargetmethodPubmedId
5BWZ DroxinostatHistone deacetylase 8 (Homo sapiens)X-RAY DIFFRACTION

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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