Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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Panobinostat

Category:HDACi
Cas Number:404950-80-7
Molecular Formula:C21H23N3O2
Molecular Weight:349.42622 g/mol
Smiles:CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO
Description:Panobinostat is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (7.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
589 PanobinostatHistone deacetylase 4 (HDAC4) (Homo sapiens (Human))21634430
590 PanobinostatHistone deacetylase 5 (HDAC5) (Homo sapiens (Human))21634430
591 PanobinostatHistone deacetylase (Homo sapiens (human))21634430
592 PanobinostatHistone deacetylase 9 (HDAC9) (Homo sapiens (Human))21634430
593 PanobinostatHistone deacetylase (HDAC1 and HDAC2) (Homo sapiens (human))21634430
594 PanobinostatHistone deacetylase 3 (Homo sapiens (human))21634430
595 PanobinostatHistone deacetylase (Homo sapiens (human))21634430
596 PanobinostatHistone deacetylase 1 (HDAC1) (Homo sapiens (human))21634430
597 PanobinostatHistone deacetylase (Homo sapiens (human))21634430
598 PanobinostatHistone deacetylase 8 (Homo sapiens (human))21634430
599 PanobinostatHistone Deacetylase 10 (HDAC10) (Homo sapiens (human))21634430
600 PanobinostatHistone deacetylase 1 (HDAC1) (Homo sapiens (human))26640968
601 PanobinostatHistone deacetylase 3 (Homo sapiens (human))26640968
602 PanobinostatHistone deacetylase 4 (HDAC4) (Homo sapiens (Human))26640968
603 PanobinostatHistone deacetylase 5 (HDAC5) (Homo sapiens (Human))26640968
604 Panobinostatistone deacetylase 6 (HDAC6) (Homo sapiens (Human))26640968
605 PanobinostatHistone deacetylase (Homo sapiens (human))26640968
606 PanobinostatHistone deacetylase 8 (Homo sapiens (human))26640968
607 PanobinostatHistone Deacetylase (pfHDAC-1) (Plasmodium falciparum (isolate 3D7))19317450
608 PanobinostatHistone deacetylase 1 (HDAC1) (Homo sapiens (human))21634430
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Disease list

ConditionsDrug NameStatusNct NumberPhases
multiple myeloma
MM
PanobinostatCompletedapproved(NDA205353)
Breast cancerPanobinostatTerminatedNCT00993642Phase 0
Cancer
advanced solid tumor
PanobinostatCompletedNCT00739414Phase 1
HER-2 positive breast cancer
metastatic breast cancer
Panobinostat
trastuzumab
paclitaxel
CompletedNCT00788931Phase 1
Breast cancerPanobinostat
trastuzumab
CompletedNCT00567879Phase 1
CancerPanobinostatCompletedNCT00570284Phase 1
Tumors
cutaneous T-cell lymphoma
PanobinostatCompletedNCT00412997Phase 1
Non-Hodgkin lymphoma
neoplasms
PanobinostatCompletedNCT00503451Phase 1
Lymphoma
leukemia
multiple myeloma
PanobinostatCompletedNCT00621244Phase 1 2
Non-Hodgkin’s lymphomaPanobinostatTerminatedNCT01090973Phase 2
LeukemiaPanobinostatCompletedNCT00723203Phase 2
Cutaneous T-cell lymphoma
leukemiaelymphoma
PanobinostatTerminatedNCT00699296Phase 2
Recurrent malignant gliomasPanobinostatTerminatedNCT00848523Phase 2
Small cell lung carcinomaPanobinostatCompletedNCT01222936Phase 2
Cutaneous T-cell lymphomaPanobinostatCompletedNCT00490776Phase 2 3
Chronic myelogenous leukemiaPanobinostatPreclinical study
epithelioid SarcomaPanobinostatPreclinical study
Ishikawa H endometrial cancerPanobinostatPreclinical study
endometrial cancerPanobinostatPreclinical study
prostate cancerTrichostatin A
Suberoylanilide hydroxamic acid
Panobinostat
Preclinical study
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High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
RNAseq to investigate transcriptional changes in human MM cell lines due to panobinostat, 5-Azacytidine, panobinostat+5-Azacytidine or n-methyl-2-pyrroldine (NMP) treatments. 5-Azacytidine
Panobinostat
DNMTi
HDACi
human Multiple myeloma cell lines24030150
24813887
Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate PanobinostatHDACihuman Chronic myelogenous leukemia CD34+ cells20478526
Gene expression profiling of histone deacetylase inhibition in epithelioid sarcoma. Drug Names:Panobinostat (HDACi) PanobinostatHDACihuman epithelioid Sarcoma cells (VAESBJ, HS-ES, Epi544)26396249
Expression data from metadherin (MTDH) knockdown in the Ishikawa H endometrial cancer cell line PanobinostatHDACi human Ishikawa H endometrial cancer cell line21687633
Expression data from MTDH knockdown in the Hec50co endometrial cancer cell line PanobinostatHDACi human hec50co endometrial cancer cell lines 21687633
Effect of HDAC inhibitors on expression of androgen induced genes Trichostatin A
Suberoylanilide hydroxamic acid
Panobinostat
HDACi human LNCaP prostate cancer cells19176386
HDACI and DAC induce specific epigenetic profile in DLBCL Panobinostat
Suberoylanilide hydroxamic acid
HDACihuman diffuse large B-cell lymphoma cells (DLBCL)21772049
Preclinical antitumor activity of ST7612AA1: a novel second generation oral histone deacetylase (HDAC) inhibitor PanobinostatHDACi human lymphoma cell lines 25671299
Aberrant chromatin acetylation in MLL-AF9 leukemia mediates the response to HDAC inhibition (microarray) PanobinostatHDACi human hematopoietic stem/progenitor cells
The HDAC inhibitor panobinostat acts as a sensitizer for erlotinib activity in EGFR mutated and wildtype NSCLC cells PanobinostatHDACihuman NSCLC cell lines (HCC827, A549 and NCI-H460)
Analysis of gene expression in human malignant rhabdoid cells following prolonged treatment with the histone deacetylase inhibitor, Panobinostat PanobinostatHDACihuman malignant rhabdoid tumor cell lines (G401, SJSC, STM91-01)
A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation, and optimization for histone deacetylase inhibitors Valproic acid
trichostatin A
Suberoylanilide hydroxamic acid
Belinostat
Panobinostat
Entinostat
HDACihuman embryonic stem cells (hESCs)26272509
Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas 5-Aza-2'-deoxycytidine
Panobinostat
DNMTi
HDACi
MDS and AML patients
miRNA expression of lymphoma cell lines with or without HDAC inhibitor treatment Suberoylanilide hydroxamic acid
Panobinostat
HDACiCTCL cell lines (My-La; HH; HUT78) and CD4+ T-cells?
Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas JQ1
panobinostat
PAHi
HDACi
Neuroblastoma SK-N-BE(2) cells
Aberrant chromatin acetylation in MLL-AF9 leukemia mediates the response to HDAC inhibition panobinostatHDACiMLL-AF9 leukemia
The HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model panobinostat HDACihuman ALL mice model 22307227
U937 treated with decitabine, panobinostat and valproic acid 5-Aza-2'-deoxycytidine
panobinostat
valproic acid
DNMTi
HDACi
AML cell line model U937

Complex list

PDBIdDrug NameTargetmethodPubmedId
5EF8 PanobinostatHdac6 protein (Danio rerio)X-RAY DIFFRACTION27454933

About

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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