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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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Trichostatin A

Category:HDACi
Cas Number:58880-19-6
Molecular Formula:C17H22N2O3
Molecular Weight:302.36818 g/mol
Smiles:CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
Description:Trichostatin A is a natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and specifically inhibits histone deacetylases, resulting in hyperacetylation of core histones which modulate chromatin structure. The increase in histone acetylation promotes selective gene transcription and the inhibition of tumor growth. This agent is a potent inducer of tumor cell growth arrest, differentiation and apoptosis in a variety of transformed cells in culture and in tumor-bearing animals.
synonyms:
Structure:
3D Conformer:3D View
Downlaod:Structure File Download (7.0KB)

Target list

IdDrug NameTargetPubmedIdCo-crystal Complex
611 Trichostatin AHistone deacetylase (Homo sapiens (human))17257837
612 Trichostatin AHistone deacetylase 1 (HDAC1) (Homo sapiens (human))20223566
613 Trichostatin AHistone deacetylase 3/Nuclear receptor corepressor 2 (Homo sapiens (human))17257837
614 Trichostatin AHistone deacetylase 3 (Homo sapiens (human))20223566
615 Trichostatin AHistone deacetylase (HDAC1 and HDAC2) (Homo sapiens (human))20223566
616 Trichostatin AHistone deacetylase (Homo sapiens (human))20223566
617 Trichostatin AHistone Deacetylase 10 (HDAC10) (Homo sapiens (human))20223566
618 Trichostatin AHistone deacetylase 8 (Homo sapiens (human))20223566
619 Trichostatin AHistone deacetylase-like amidohydrolase (Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)19457659
620 Trichostatin AHistone deacetylase 1 (HDAC1) (Homo sapiens (human))16439135
621 Trichostatin AHistone deacetylase 4 (HDAC4) (Homo sapiens (Human))16439135
622 Trichostatin AHistone Deacetylase 6 (HDAC6) (Mus musculus)16439135
623 Trichostatin AHistone Deacetylase 6 (HDAC6) (Mus musculus)17929798
624 Trichostatin AHistone deacetylase 1 (HDAC1) (Homo sapiens (human))17929798
625 Trichostatin AHistone deacetylase 4 (HDAC4) (Homo sapiens (Human))17929798
626 Trichostatin AHistone deacetylase (Homo sapiens (human))18494463
627 Trichostatin AHistone deacetylase 8 (Homo sapiens (human))18494463
628 Trichostatin AHistone deacetylase 1 (HDAC1) (Homo sapiens (human))18494463
629 Trichostatin AHistone deacetylase 3 (Homo sapiens (human))18494463
630 Trichostatin AHistone Deacetylase 10 (HDAC10) (Homo sapiens (human))18494463
Total Page:11 Page   of 11

Disease list

ConditionsDrug NameStatusNct NumberPhases
embryonal rhabdomyosarcomaTrichostatin A
Suberoylanilide hydroxamic acid
Preclinical study
cervical carcinomaTrichostatin A
Suberoylanilide hydroxamic acid
Preclinical study
healthyTrichostatin A
Suberoylanilide hydroxamic acid
Preclinical study
BCPAP papillary thyroid carcinomaTrichostatin A
Suberoylanilide hydroxamic acid
Preclinical study
diffuse large B-cell lymphomasSuberoylanilide hydroxamic acid
Valproic acid
Trichostatin A
Preclinical study
Burkitts lymphomaTrichostatin APreclinical study
prostate cancerTrichostatin A
Suberoylanilide hydroxamic acid
Panobinostat
Preclinical study
non-small cell lung cancer (NSCLC)Trichostatin A
Suberoylanilide hydroxamic acid
Preclinical study
Prostate CancerTrichostatin A
CG-1521
Preclinical study
endothelial tumorTrichostatin A
5-Aza-2'-deoxycytidine
Preclinical study
healthyTrichostatin APreclinical study
healthyTrichostatin APreclinical study
healthyValproic acid
trichostatin A
Suberoylanilide hydroxamic acid
Belinostat
Panobinostat
Entinostat
Preclinical study
prostate cancer5-Azacytidine
Trichostatin A
Preclinical study
breast cancer5-Azacytidine
Trichostatin A
3-Deazaneplanocin A
Preclinical study
colorectal cancertrichostatin A
5-Aza-2'-deoxycytidine
Preclinical study
cervical carcinomatrichostatin A Preclinical study
colon carcinomaGSK126
Trichostatin A
Preclinical study
colon carcinomatrichostatin APreclinical study
Hodgkin lymphoma5-Aza-2'-deoxycytidine
Trichostatin A
Preclinical study
Total Page:3 Page   of 3

High-throughoutput Dataset

TitleDrug NameCategorySample typePMID
Genome-wide microRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers 5-Aza-2'-deoxycytidine
trichostatin A
DNMTi
HDACi
human non-small cell lung cancers cells (A549) 22282464
Histone deacetylase inhibitors antagonize distinct pathways to suppress tumorigenesis of embryonal rhabdomyosarcoma. Trichostatin A
Suberoylanilide hydroxamic acid
HDACihuman embryonal rhabdomyosarcoma cells (RD and 381T)26636678
Histone deacetylase inhibitors cause the selective depletion of bromodomain containing proteins Trichostatin A
Suberoylanilide hydroxamic acid
HDACi human cervical carcinoma passage cells ( HeLa cells )25755299
Vascular histone deacetylation by pharmacological HDAC inhibition [TSA, ChIP-seq] Trichostatin A
Suberoylanilide hydroxamic acid
HDACi human vascular endothelial cells24732587
Effect of histone deacetylase inhibitors on miRNA expression in thyroid cancer cells Trichostatin A
Suberoylanilide hydroxamic acid
HDACihuman BCPAP papillary thyroid carcinoma cells21946411
BCL6 repression of EP300 provides a basis for rational combinatorial therapy in diffuse large B cell lymphomas Suberoylanilide hydroxamic acid
Valproic acid
Trichostatin A
HDACihuman diffuse large B-cell lymphomas cell lines (DLBCL cell lines)21041953
Expression of the TM4SF member CD9 on the human Burkitts lymphoma cell line Raji Trichostatin AHDACi human Burkitts lymphoma cell line Raji
Effect of HDAC inhibitors on expression of androgen induced genes Trichostatin A
Suberoylanilide hydroxamic acid
Panobinostat
HDACi human LNCaP prostate cancer cells19176386
Anti-tumor Activity of Histone Deacetylase Inhibitors in Non-Small Cell Lung Cancer Cells Trichostatin A
Suberoylanilide hydroxamic acid
HDACi human non-small cell lung cancer (NSCLC)18606719
7.5uM CG-1521 and 5uM TSA treatment of LNCaP Prostate Cancer cells Trichostatin A
CG-1521
HDACi human LNCaP Prostate Cancer cells18645003
Identification of epigenetically silenced genes in tumor endothelial cells Trichostatin A
5-Aza-2'-deoxycytidine
DNMTi
HDACi
human tumor endothelial cells17483324
Targets of pharmacological histone deacetylase inhibition in human umbilical vein endothelial cells Trichostatin AHDACi human umbilical vein endothelial cells (HUVEC)
Gene expression induced by TSA in undifferentiated human primary myoblasts versus terminally differentiated human myotubes Trichostatin AHDACihuman primary myoblasts and terminally differentiated human myotubes
A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation, and optimization for histone deacetylase inhibitors Valproic acid
trichostatin A
Suberoylanilide hydroxamic acid
Belinostat
Panobinostat
Entinostat
HDACihuman embryonic stem cells (hESCs)26272509
MicroRNA-1 is a candidate tumor suppressor and prognostic marker 5-Azacytidine
Trichostatin A
DNMTi
HDACi
human prostate cancer LNCaP cells22210864
Combinatorial pharmacological approaches target EZH2-mediated gene repression in breast cancer cells 5-Azacytidine
Trichostatin A
3-Deazaneplanocin A
DNMTi
HDACi
HMTi
human breast cancer cells (MCF-7)19934278
Epigenotyping by quantitative DNA methylation analysis revealed three epigenotypes in colorectal cancer trichostatin A
5-Aza-2'-deoxycytidine
HDACi
DNMTi
MSI-high CRC cell line HCT11620028768
Aberrant heterochromatic foci are associated to deregulation of the GMCL1 gene in CH1 lymphoma B cells trichostatin AHDACiHeLa S3 cells and Calu-4 cells
Finding missing proteins from epigenetically manipulated human cells GSK126
Trichostatin A
HMTi
HDACi
A549; HCT116 and MHCC97H cells26202631
Histone deacetylase inhibition enhances antimicrobial peptide but not inflammatory cytokine expression upon bacterial challenge trichostatin AHDACihuman Caco-2 cells (subclone TC7)27162363
Total Page:3

Complex list

PDBIdDrug NameTargetmethodPubmedId
1T64 Trichostatin AHistone deacetylase 8 (Homo sapiens)X-RAY DIFFRACTION15242608
1C3R Trichostatin AHDLP (HISTONE DEACETYLASE-LIKE PROTEIN) (Aquifex aeolicus)X-RAY DIFFRACTION10490031
3C10 Trichostatin AHistone deacetylase 7a (Homo sapiens)X-RAY DIFFRACTION18285338
3F0R Trichostatin AHistone deacetylase 8 (Homo sapiens)X-RAY DIFFRACTION19053282
4QA3 Trichostatin AHistone deacetylase 8 (Homo sapiens)X-RAY DIFFRACTION25075551

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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