HEDD

Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

Trichostatin A

Category:	HDACi
Cas Number:	58880-19-6
Molecular Formula:	C₁₇H₂₂N₂O₃
Molecular Weight:	302.36818 g/mol
Smiles:	CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
Description:	Trichostatin A is a natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and specifically inhibits histone deacetylases, resulting in hyperacetylation of core histones which modulate chromatin structure. The increase in histone acetylation promotes selective gene transcription and the inhibition of tumor growth. This agent is a potent inducer of tumor cell growth arrest, differentiation and apoptosis in a variety of transformed cells in culture and in tumor-bearing animals.
synonyms:	trichostatin A 58880-19-6 Trichostatin TSA CHEBI:46024 GNF-PF-1011 [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide TSA, Trichostatin A 2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo- 7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide Tricostatin A 7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE 2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- TSN Trichlostatin A (2E,4E,6R)-7-(4-Dimethylaminophenyl)-N-hydroxy-4,6-dimethyl-7-oxo-hepta-2,4-dienamide 7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide Trichostatin A,TSA Trichostatin A/TSA Antibiotic A-300 (R)-Trichostatin A S1045_Selleck NCGC_TSA 1c3r 3f0r Trichostatin-A - TSA AC1L9GSU A 300 SCHEMBL19886 MLS006011095 SGCTO-002 Ambotz58880-19-6 SCHEMBL675951 T8552_SIGMA UNII-3X2S926L3Z GTPL7005 MolPort-003-959-819 RTKIYFITIVXBLE-QEQCGCAPSA-N 3X2S926L3Z BCPP000035 HMS1362L09 HMS1792L09 HMS1990L09 HMS3403L09 HMS3649O20 ABP000141 BDBM50005711 DNC001465 LMPK01000055 MFCD03848392 Trichostatin A from Streptomyces sp. AKOS015899840 ZINC100014731 A-300-I CCG-208142 CCG-208681 CS-0499 DB04297 RL04219 NCGC00162453-01 NCGC00162453-02 NCGC00162453-03 NCGC00162453-04 NCGC00162453-05 Trichostatin A, TSA, 58880-19-6 3C10 HY-15144 KB-81257 LS-74195 M984 SMR004702883 A8183 FT-0698647 Trichostatin A-Supplied by Selleck Chemicals M02571 W-5309 Q-201864 BRD-K68202742-001-04-1 BRD-K68202742-001-05-8 I14-11732 (2E,4E,6R)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide (2E,4E,6R)-7-(4-dimethylaminophenyl)-4,6-dimethyl-7-oxo-hepta-2,4-dienehydroxamic acid (2E,4E,6R)-7-(4-dimethylaminophenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide (6R)-N-Hydroxy-4,6-dimethyl-7-oxo-7-[4-(dimethylamino)phenyl]-2,4-heptadienamide (R,2E,4E)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide 7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- (9CI) 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, [R-(E,E)]-
Structure:
3D Conformer:	3D View
Downlaod:	Structure File Download (7.0KB)

Target list

Id	Drug Name	Target	PubmedId	Co-crystal Complex
611	Trichostatin A	Histone deacetylase (Homo sapiens (human))	17257837
612	Trichostatin A	Histone deacetylase 1 (HDAC1) (Homo sapiens (human))	20223566
613	Trichostatin A	Histone deacetylase 3/Nuclear receptor corepressor 2 (Homo sapiens (human))	17257837
614	Trichostatin A	Histone deacetylase 3 (Homo sapiens (human))	20223566
615	Trichostatin A	Histone deacetylase (HDAC1 and HDAC2) (Homo sapiens (human))	20223566
616	Trichostatin A	Histone deacetylase (Homo sapiens (human))	20223566
617	Trichostatin A	Histone Deacetylase 10 (HDAC10) (Homo sapiens (human))	20223566
618	Trichostatin A	Histone deacetylase 8 (Homo sapiens (human))	20223566
619	Trichostatin A	Histone deacetylase-like amidohydrolase (Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)	19457659
620	Trichostatin A	Histone deacetylase 1 (HDAC1) (Homo sapiens (human))	16439135
621	Trichostatin A	Histone deacetylase 4 (HDAC4) (Homo sapiens (Human))	16439135
622	Trichostatin A	Histone Deacetylase 6 (HDAC6) (Mus musculus)	16439135
623	Trichostatin A	Histone Deacetylase 6 (HDAC6) (Mus musculus)	17929798
624	Trichostatin A	Histone deacetylase 1 (HDAC1) (Homo sapiens (human))	17929798
625	Trichostatin A	Histone deacetylase 4 (HDAC4) (Homo sapiens (Human))	17929798
626	Trichostatin A	Histone deacetylase (Homo sapiens (human))	18494463
627	Trichostatin A	Histone deacetylase 8 (Homo sapiens (human))	18494463
628	Trichostatin A	Histone deacetylase 1 (HDAC1) (Homo sapiens (human))	18494463
629	Trichostatin A	Histone deacetylase 3 (Homo sapiens (human))	18494463
630	Trichostatin A	Histone Deacetylase 10 (HDAC10) (Homo sapiens (human))	18494463

Disease list

Conditions	Drug Name	Status	Nct Number	Phases
embryonal rhabdomyosarcoma	Trichostatin A Suberoylanilide hydroxamic acid			Preclinical study
cervical carcinoma	Trichostatin A Suberoylanilide hydroxamic acid			Preclinical study
healthy	Trichostatin A Suberoylanilide hydroxamic acid			Preclinical study
BCPAP papillary thyroid carcinoma	Trichostatin A Suberoylanilide hydroxamic acid			Preclinical study
diffuse large B-cell lymphomas	Suberoylanilide hydroxamic acid Valproic acid Trichostatin A			Preclinical study
Burkitts lymphoma	Trichostatin A			Preclinical study
prostate cancer	Trichostatin A Suberoylanilide hydroxamic acid Panobinostat			Preclinical study
non-small cell lung cancer (NSCLC)	Trichostatin A Suberoylanilide hydroxamic acid			Preclinical study
Prostate Cancer	Trichostatin A CG-1521			Preclinical study
endothelial tumor	Trichostatin A 5-Aza-2'-deoxycytidine			Preclinical study
healthy	Trichostatin A			Preclinical study
healthy	Trichostatin A			Preclinical study
healthy	Valproic acid trichostatin A Suberoylanilide hydroxamic acid Belinostat Panobinostat Entinostat			Preclinical study
prostate cancer	5-Azacytidine Trichostatin A			Preclinical study
breast cancer	5-Azacytidine Trichostatin A 3-Deazaneplanocin A			Preclinical study
colorectal cancer	trichostatin A 5-Aza-2'-deoxycytidine			Preclinical study
cervical carcinoma	trichostatin A			Preclinical study
colon carcinoma	GSK126 Trichostatin A			Preclinical study
colon carcinoma	trichostatin A			Preclinical study
Hodgkin lymphoma	5-Aza-2'-deoxycytidine Trichostatin A			Preclinical study

High-throughoutput Dataset

Title	Drug Name	Category	Sample type	PMID
Genome-wide microRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers	5-Aza-2'-deoxycytidine trichostatin A	DNMTi HDACi	human non-small cell lung cancers cells (A549)	22282464
Histone deacetylase inhibitors antagonize distinct pathways to suppress tumorigenesis of embryonal rhabdomyosarcoma.	Trichostatin A Suberoylanilide hydroxamic acid	HDACi	human embryonal rhabdomyosarcoma cells (RD and 381T)	26636678
Histone deacetylase inhibitors cause the selective depletion of bromodomain containing proteins	Trichostatin A Suberoylanilide hydroxamic acid	HDACi	human cervical carcinoma passage cells ( HeLa cells )	25755299
Vascular histone deacetylation by pharmacological HDAC inhibition [TSA, ChIP-seq]	Trichostatin A Suberoylanilide hydroxamic acid	HDACi	human vascular endothelial cells	24732587
Effect of histone deacetylase inhibitors on miRNA expression in thyroid cancer cells	Trichostatin A Suberoylanilide hydroxamic acid	HDACi	human BCPAP papillary thyroid carcinoma cells	21946411
BCL6 repression of EP300 provides a basis for rational combinatorial therapy in diffuse large B cell lymphomas	Suberoylanilide hydroxamic acid Valproic acid Trichostatin A	HDACi	human diffuse large B-cell lymphomas cell lines (DLBCL cell lines)	21041953
Expression of the TM4SF member CD9 on the human Burkitts lymphoma cell line Raji	Trichostatin A	HDACi	human Burkitts lymphoma cell line Raji
Effect of HDAC inhibitors on expression of androgen induced genes	Trichostatin A Suberoylanilide hydroxamic acid Panobinostat	HDACi	human LNCaP prostate cancer cells	19176386
Anti-tumor Activity of Histone Deacetylase Inhibitors in Non-Small Cell Lung Cancer Cells	Trichostatin A Suberoylanilide hydroxamic acid	HDACi	human non-small cell lung cancer (NSCLC)	18606719
7.5uM CG-1521 and 5uM TSA treatment of LNCaP Prostate Cancer cells	Trichostatin A CG-1521	HDACi	human LNCaP Prostate Cancer cells	18645003
Identification of epigenetically silenced genes in tumor endothelial cells	Trichostatin A 5-Aza-2'-deoxycytidine	DNMTi HDACi	human tumor endothelial cells	17483324
Targets of pharmacological histone deacetylase inhibition in human umbilical vein endothelial cells	Trichostatin A	HDACi	human umbilical vein endothelial cells (HUVEC)
Gene expression induced by TSA in undifferentiated human primary myoblasts versus terminally differentiated human myotubes	Trichostatin A	HDACi	human primary myoblasts and terminally differentiated human myotubes
A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation, and optimization for histone deacetylase inhibitors	Valproic acid trichostatin A Suberoylanilide hydroxamic acid Belinostat Panobinostat Entinostat	HDACi	human embryonic stem cells (hESCs)	26272509
MicroRNA-1 is a candidate tumor suppressor and prognostic marker	5-Azacytidine Trichostatin A	DNMTi HDACi	human prostate cancer LNCaP cells	22210864
Combinatorial pharmacological approaches target EZH2-mediated gene repression in breast cancer cells	5-Azacytidine Trichostatin A 3-Deazaneplanocin A	DNMTi HDACi HMTi	human breast cancer cells (MCF-7)	19934278
Epigenotyping by quantitative DNA methylation analysis revealed three epigenotypes in colorectal cancer	trichostatin A 5-Aza-2'-deoxycytidine	HDACi DNMTi	MSI-high CRC cell line HCT116	20028768
Aberrant heterochromatic foci are associated to deregulation of the GMCL1 gene in CH1 lymphoma B cells	trichostatin A	HDACi	HeLa S3 cells and Calu-4 cells
Finding missing proteins from epigenetically manipulated human cells	GSK126 Trichostatin A	HMTi HDACi	A549; HCT116 and MHCC97H cells	26202631
Histone deacetylase inhibition enhances antimicrobial peptide but not inflammatory cytokine expression upon bacterial challenge	trichostatin A	HDACi	human Caco-2 cells (subclone TC7)	27162363

Complex list

PDBId	Drug Name	Target	method	PubmedId
1T64	Trichostatin A	Histone deacetylase 8 (Homo sapiens)	X-RAY DIFFRACTION	15242608
1C3R	Trichostatin A	HDLP (HISTONE DEACETYLASE-LIKE PROTEIN) (Aquifex aeolicus)	X-RAY DIFFRACTION	10490031
3C10	Trichostatin A	Histone deacetylase 7a (Homo sapiens)	X-RAY DIFFRACTION	18285338
3F0R	Trichostatin A	Histone deacetylase 8 (Homo sapiens)	X-RAY DIFFRACTION	19053282
4QA3	Trichostatin A	Histone deacetylase 8 (Homo sapiens)	X-RAY DIFFRACTION	25075551

About

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.