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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting

Drug Name:5-azacytidine
Drug Category: DNMTi
Sample Type:human T lymphocytes
Condition:breast cancer ,colorectal cancer ,ovarian cance
Experiment Type:Methylation profiling by array
Experiment Platform:GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Description:Epigenetic therapy is emerging as a potential therapy for solid tumors. To investigate its mechanism of action, we performed integrative expression and methylation analysis of 63 cancer cell lines (breast, colorectal, and ovarian) after treatment with the DNA methyltransferase inhibitor 5-azacitidine (AZA). Gene Set Enrichment Analysis demonstrated significant enrichment for immunomodulatory pathways in all three cancers (14.4-31.3%) including interferon signaling, antigen processing and presentation, and cytokines/chemokines. Strong upregulation of cancer testis antigens was also observed. An AZA IMmune gene set (AIMs) derived from the union of these immunomodulatory pathway genes classified primary tumors from all three types, into "high" and "low" AIM gene expression subsets in tumor expression data from both TCGA and GEO. Samples from selected patient biopsies showed upregulation of AIM genes after treatment with epigenetic therapy. These results point to a broad immune stimulatory role for DNA demethylating drugs in multiple cancers.
PubmedID:24583822
Citation:Li H;Chiappinelli KB;Guzzetta AA;Easwaran H;Yen RW;Vatapalli R;Topper MJ;Luo J;Connolly RM;Azad NS;Stearns V;Pardoll DM;Davidson N;Jones PA;Slamon DJ;Baylin SB;Zahnow CA;Ahuja N. Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers. Oncotarget 2014 Feb 15;5(3):587-98.
Downlaod:Relative Link

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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