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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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Gene repression with H3K27me3 modification in human small cell lung cancer

Drug Name:3-Deazaneplanocin A
Drug Category:HMTi
Sample Type:clinical SCLC samples; normal tissue samples; small cell lung cancer (SCLC) cell lines; normal small airway epithelial cell (SAEC)?
Condition:small cell lung cancer (SCLC)
Experiment Type:Expression profiling by array
Experiment Platform:GPL96 [HG-U133A] Affymetrix Human Genome U133A Array ;GPL97 [HG-U133B] Affymetrix Human Genome U133B Array ;GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Description:Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. Expression array analysis of 23 SCLC cases and 42 normal tissues revealed that EZH2 and other PRC2 members were highly expressed in SCLC. ChIP-seq for H3K27me3 suggested that genes with H3K27me3(+) in SCLC were extended not only to PRC2-target genes in ES cells but also to other target genes such as cellular adhesion-related genes. These H3K27me3(+) genes in SCLC were repressed significantly, and introduction of the most repressed gene JUB into SCLC cell line lead to growth inhibition. Shorter overall survival of clinical SCLC cases correlated to repression of JUB alone, or a set of four genes including H3K27me3(+) genes. Treatment with EZH2 inhibitors, DZNep and GSK126, resulted in growth repression of SCLC cell lines. High PRC2 expression was suggested to contribute to gene repression in SCLC, and may play a role in genesis of SCLC.
PubmedID:23714854
Citation:Sato T; Kaneda A;Tsuji S;Isagawa T;Yamamoto S;Fujita T;Yamanaka R;Tanaka Y;Nukiwa T;Marquez VE;Ishikawa Y;Ichinose M;Aburatani H. PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer. Sci Rep 2013;3:1911.
Downlaod:File Download (542.861MB)

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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