Welcome to HEDD

The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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Pargyline

Target:Monoamine oxidase (Homo sapiens (Human))
Ki(nM):
IC50(nM):188
Ki(nM):
EC50(nM):
Description:Inhibition of recombinant human MAO-B using p-benzylamine substrate preincubated for 15 mins before substrate addition measured after 20 mins by fluorescence assay
PubmedID:23454517
Citation:Lu, C; Zhou, Q; Yan, J; Du, Z; Huang, L; Li, X A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease. Eur J Med Chem62:745-53 (2013)
Co-crystal Complex:

Explanation

Ki: The measure of bond-tightness between an enzyme and a corresponding enzyme inhibitor.

IC50: The half maximal inhibitory concentration is a measure of the effectiveness of a substance in inhibiting a specific biological or biochemical function.

Kd: The dissociation constant is a specific type of equilibrium constant that measures the propensity of a larger object to separate reversibly into smaller components.

EC50: The term half maximal effective concentration refers to the concentration of a drug, antibody or toxicant which induces a response halfway between the baseline and maximum after a specified exposure time.

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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