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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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carbamazepine

Target:Cytochrome P450 3A (Homo sapiens (human))
Ki(nM):
IC50(nM):
Ki(nM):
EC50(nM):
Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. CYP3A4A is thought to be one of the primary CYP isoforms responsible for retinoic acid metabolism in the skin. Three benchmark agents, liarozole, climbazole, and ketoconazole, were assessed for CYP3A4 inhibition to confirm that the inhibition activity (the IC50 for CYP3A4 inhibition) measured by the assay corresponds to the activity reported by the published literature. The results show that the substituted azole compounds having the specific structure set forth herein are CYP inhibitors, and thus function as RAMBAs.
PubmedID:
Citation:Bareja, SP; Jones, SD; Oblong, JE; Mills, KJ; Bierman, JC Cosmetic compositions containing substituted azole and methods for improving the appearance of aging skin US Patent US9138393 Publication Date 9/22/2015
Co-crystal Complex:

Explanation

Ki: The measure of bond-tightness between an enzyme and a corresponding enzyme inhibitor.

IC50: The half maximal inhibitory concentration is a measure of the effectiveness of a substance in inhibiting a specific biological or biochemical function.

Kd: The dissociation constant is a specific type of equilibrium constant that measures the propensity of a larger object to separate reversibly into smaller components.

EC50: The term half maximal effective concentration refers to the concentration of a drug, antibody or toxicant which induces a response halfway between the baseline and maximum after a specified exposure time.

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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