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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on the storage and integration of epigenetic drug datasets that were obtained from laboratory experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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carbamazepine

Target:Voltage-gated potassium channel (Homo sapiens (human))
Ki(nM):
IC50(nM):104712.85
Ki(nM):
EC50(nM):
Description:Inhibition of human ERG
PubmedID:21185626
Citation:Sinha, N; Sen, S Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. Eur J Med Chem46:618-30 (2011)
Co-crystal Complex:

Explanation

Ki: The measure of bond-tightness between an enzyme and a corresponding enzyme inhibitor.

IC50: The half maximal inhibitory concentration is a measure of the effectiveness of a substance in inhibiting a specific biological or biochemical function.

Kd: The dissociation constant is a specific type of equilibrium constant that measures the propensity of a larger object to separate reversibly into smaller components.

EC50: The term half maximal effective concentration refers to the concentration of a drug, antibody or toxicant which induces a response halfway between the baseline and maximum after a specified exposure time.

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The Human Epigenetic Drug Database (HEDD) is a comprehensive web-based database for epigenetic drugs, which focuses on integrating epigenetic drug studies based Omics data from high through experiments that is essential for understanding the mechanism of action of these epigenetic drugs at a systematic level.

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©2016 Group of Computational Epigenomics and Bioinformatics, College of Life Science, Jilin Normal University, China

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